A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease [PDF]
, 2007 Dupuytren’s disease (DD) is a common fibrotic condition of the palmar fascia, leading to deposition of collagen-rich cords and finger contractions. The metzincin superfamily contains key enzymes in the turnover of collagen and other extracellular matrix ...
Adrian J. Chojnowski +48 more
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The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs
Pulmonary Medicine, 2022 Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP).
Louis Costanzo +3 more
doaj +1 more source
Promoting uptake and integration of climate smart agriculture technologies, innovations and management practices into policy and practice in Nigeria [PDF]
International Journal of Climate Change Strategies and Management, 2022 Purpose – This study aims to explore possible ways to promote uptake and integration of climate-smart agriculture (CSA)-Technologies, Innovations and Management Practices (TIMPS) into policy and practice in Nigeria through the development of actionable ...
Chinwoke Clara Ifeanyi-Obi +5 more
doaj +1 more source
Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]
, 2011 Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Amento +91 more
core +1 more source
The in vitro activity of ADAM‐10 is inhibited by TIMP‐1 and TIMP‐3 [PDF]
FEBS Letters, 2000 A recombinant soluble form of the catalytic domain of human ADAM‐10 was expressed as an Fc fusion protein from myeloma cells. The ADAM‐10 was catalytically active, cleaving myelin basic protein and peptides based on the previously described ‘metallosheddase’ cleavage sites of tumour necrosis factor α, CD40 ligand and amyloid precursor protein.
Amour, Augustin +7 more
openaire +2 more sources
Neisseria gonorrhoeae challenge increases matrix metalloproteinase-8 expression in fallopian tube explants [PDF]
, 2017 Indexación: Scopus.Background: Neisseria gonorrhoeae (Ngo) is the etiological agent of gonorrhea, a sexually transmitted infection that initially infects the female lower genital tract.
Cristobal Muñoz +9 more
core +2 more sources
Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]
, 2012 Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Alan Prem Kumar +14 more
core +17 more sources
Microbial Cell Factories, 2017 Background As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal role in extracellular matrix remodeling, which is involved in a wide variety of ...
Ki Baek Lee +5 more
doaj +1 more source
Whole organism profiling of the Timp gene family
Matrix Biology Plus, 2023 Tissue inhibitor of metalloproteinases (TIMPs/Timps) are an endogenous family of widely expressed matrisome-associated proteins that were initially identified as inhibitors of matrix metalloproteinase activity (Metzincin family proteases).
David Peeney +8 more
doaj +1 more source
MMP–TIMP interaction depends on residue 2 in TIMP‐4
FEBS Letters, 2001 Extracellular matrix remodeling and degradation are of great importance in both physiological and pathological situations. Matrix metalloproteinases (MMPs) and their natural occurring inhibitors – tissue inhibitors of metalloproteinases (TIMPs) – are involved in matrix turnover. Among the TIMPs there is only little specificity for inhibiting individual
Stratmann, B, Farr, M, Tschesche, Harald
openaire +3 more sources