Results 31 to 40 of about 16,067 (252)

Higher levels of circulating TIMP-4 in preeclampsia is strongly associated with clinical parameters and microRNA

Clinical and Experimental Hypertension, 2018
Background: Preeclampsia results in maternal and fetal complications and some studies have reported the role of MMPs and TIMPs in its pathophysiology.
Valéria C. Sandrim, Solange Diniz, Nibia Mariana Eleuterio, Karina B. Gomes, Luci Maria S. Dusse, Ricardo C. Cavalli   +5 more
doaj   +1 more source

Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment

Frontiers in Oncology, 2022
BackgroundThe tissue inhibitors of metalloproteinase (TIMPs) and their associated metalloproteinase (MMPs) are essential regulators of tissue homeostasis and are essential for cancer progression. This study analyzed the expression of TIMP-1,-2,-3 and the
Ruth M. Escalona, Ruth M. Escalona, Ruth M. Escalona, Ruth M. Escalona, George Kannourakis, George Kannourakis, Jock K. Findlay, Jock K. Findlay, Jock K. Findlay, Nuzhat Ahmed, Nuzhat Ahmed, Nuzhat Ahmed, Nuzhat Ahmed, Nuzhat Ahmed   +13 more
doaj   +1 more source

Kidney Fibrosis and Matrix Metalloproteinases (MMPs)

Frontiers in Bioscience-Landmark
Chronic kidney disease (CKD) is a disorder that causes changes in both the structure and function of the kidneys, causing complications such as hypertension, edema, and oliguria. Renal fibrosis is also a common pathological feature of CKD.
Antonella La Russa, Raffaele Serra, Teresa Faga, Giuseppina Crugliano, Angelica Bonelli, Giuseppe Coppolino, Davide Bolignano, Yuri Battaglia, Nicola Ielapi, Davide Costa, Ashour Michael, Michele Andreucci   +11 more
doaj   +1 more source

Expression of TIMP-1 and TIMP-2 in rats with hepatic fibrosis

World Journal of Gastroenterology, 2004
To investigate the location and expression of TIMP-1 and TIMP-2 in the liver of normal and experimental hepatic fibrosis in rats.The rat models of experimental immunity hepatic fibrosis (n=20) were prepared by the means of immunologic attacking with human serum albumin (HSA), and normal rats (n=10) served as control group. Both immunohistochemistry and
Qing-He, Nie, Guo-Rong, Duan, Xin-Dong, Luo, Yu-Mei, Xie, Hong, Luo, Yong-Xing, Zhou, Bo-Rong, Pan   +6 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Matrix metalloproteinases and tissue inhibitors in multiple myeloma: promote or inhibit?

Frontiers in Oncology, 2023
Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) play a vital role in the pathogenesis of multiple myeloma (MM), especially for tumor invasion and osteolytic osteopathy.
Yan-Ying Li, Yan-Ying Li, Liu-Yun Zhang, Liu-Yun Zhang, Yun-Hui Xiang, Yun-Hui Xiang, Dan Li, Juan Zhang   +7 more
doaj   +1 more source

Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients [PDF]

Journal of Neuro-Oncology, 2016
Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been associated with poor prognosis and resistance towards chemotherapy in several cancer forms. In a previous study we found an association between a low TIMP-1 tumor immunoreactivity and increased survival for glioblastoma patients, when compared to moderate and high TIMP-1 tumor immunoreactivity.
Aaberg-Jessen, Charlotte, Halle, Bo, Jensen, Stine Skov, Muller, Sven, Rømer, Maria Unni Koefoed, Pedersen, Christian B., Brünner, Nils, Kristensen, Bjarne Winther   +7 more
openaire   +5 more sources

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Expression of matrix metalloproteinases (MMPs)−2/-7/-9/-14 and tissue inhibitors of MMPs (TIMPs)−1/-2 in bovine cutaneous fibropapillomas associated with BPV-2 infection

Frontiers in Veterinary Science, 2022
IntroductionBovine papillomaviruses −1/−2 (BPVs) are small non-enveloped double-stranded DNA viruses able to infect the skin of bovids and equids, causing development of neoplastic lesions such as bovine cutaneous fibropapillomas and equine sarcoid ...
Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Oana Irina Tanase, Mihaela Anca Dascalu, Sorin Aurelian Pasca, Ozana Hritcu, Mihai Mares, Giuseppe Borzacchiello   +8 more
doaj   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source