Results 11 to 20 of about 16,067 (252)
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Detection of Matrix Metalloproteinases Patterns in Bovine Luteum cell during Pregnancy
Journal of Animal Reproduction and Biotechnology, 2018 The major focus of this study is to analyze the expression of bovine MMPs and to monitor their activity during the estrus cycle and pregnancy. During pregnancy, MMP-2 expression was detectable around 30 days but became insignificant by 60 days, then ...
Sang-Hwan Kim +6 more
doaj +1 more source
Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma
BMC Neurology, 2021 Background Tissue inhibitors of metalloproteinase (TIMP) family proteins are peptidases involved in extracellular matrix (ECM) degradation. Various diseases are related to TIMPs, and the primary reason is that TIMPs can indirectly regulate remodelling of
Jinkun Han +3 more
doaj +1 more source
Journal of Animal Reproduction and Biotechnology, 2019 We observed MMPs expression in all sperm groups, with pro-MMP showing lower expression than active MMPs. According to the results from each freezing extender, the sperm membrane integrity (HOST: Hypoosmotic Swelling Test) analysis in TCGGD (Tris 250 mM ...
Sang Hwan Kim +2 more
doaj +1 more source
BMC Pulmonary Medicine, 2020 Background Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play important roles in the turnover of extracellular matrix and in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Jamie L. Todd +14 more
doaj +1 more source
Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial disease. [PDF]
PLoS Neglected Tropical Diseases, 2012 Infection with Wuchereria bancrofti can cause severe disease characterized by subcutaneous fibrosis and extracellular matrix remodeling. Matrix metalloproteinases (MMPs) are a family of enzymes governing extracellular remodeling by regulating cellular ...
Rajamanickam Anuradha +5 more
doaj +1 more source
Journal of Animal Reproduction and Biotechnology, 2018 To determine the differences in the in-vitro ovum maturation process of bovine, we compared the expression of MMPs in these oocytes and cumulus cell throughout oocytes maturated. In an attempt to investigate the effect of MMP activation and inhibitors in
Sang-Hwan Ki, Jong-Taek Yoon
doaj +1 more source
Role of TIMP-1 and TIMP-2 in the Progression of Cerebral Aneurysms [PDF]
Stroke, 2007 Background and Purpose— The degradation of extracellular matrix (ECM) is a hallmark of a cerebral aneurysm; however, little is known regarding the molecular mechanism leading to this change. Tissue inhibitor of matrix metalloproteinase (TIMP) regulates the ECM degradation in vascular walls by ...
Tomohiro, Aoki +4 more
openaire +2 more sources
Journal of Animal Reproduction and Biotechnology, 2018 The purpose of this study was to analyze whether FSH and LH hormone treatment directly or indirectly affect embryo development in embryonic development.
Sang Hwan Kim, Jong Taek Yoon
doaj +1 more source
The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs
Pulmonary Medicine, 2022 Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP).
Louis Costanzo +3 more
doaj +1 more source