Results 161 to 170 of about 246,934 (340)

Matrix metalloproteinases (MMPs) and pancreatic diseases

Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and
Tanizaki, Yoshiro, Mizushima, Takaaki, Ochi, Koji, Mitsunobu, Fumihiro, Yokoyama, Motohiro, Tsurumi, Tetsuya, Ichimura, Mitsuko   +6 more
core  

Metaloproteinasas de la matriz extracelular (MMPs) en Odontología

, 2016
Most body tissues are found in a constant renovation process, modulated by a large number of proteins that induce tissue synthesis and degradation over time.
Bueno Rossy, Luis, Pereira Prado, Vanesa, Asquino, Natalia, Apellaniz, Delmira, Bologna Molina, Ronell, Tapia, Gabriel   +5 more
core  

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Role of MMPs and CD147 in non-alcoholic steatohepatitis progression

, 2015
Obesity and diabetes is increasing exponentially and this is accompanied with prevalence of metabolic diseases like non-alcoholic steatohepatitis (NASH), an inflammatory often fibrotic condition of the liver.
Mridha, Auvro Robin
core  

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Regulation der zellulären Oberflächenexposition von löslichen MMPs in primären humanen Makrophagen

, 2023
Matrix-Metalloproteasen (MMPs) sind zinkabhängige Endopeptidasen, die vor allem Bestandteile der extrazellulären Matrix (EZM) wie Kollagene, Fibronektine und Laminine, aber auch für die Adhäsion verantwortliche Proteine wie Integrine oder auch andere ...
Ratt, Artur
core  

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Plasma Levels of Matrilysins (MMP-7 and MMP-26) and Stromelysins (MMP-3 and MMP-10) in Diagnosis of Endometrial Cancer Patients

International Journal of Molecular Sciences
Metalloproteinases (MMPs) play a significant role in cancer pathogenesis. We investigated the levels of MMP-7, MMP-26, MMP-3, and MMP-10 in comparison with the levels of a tumor marker (CA125) in the plasma of postmenopausal patients in early stages of endometrial cancer (EC) compared with control groups: patients with benign lesions (myoma uteri) and ...
Ewa Gacuta, Michał Ławicki, Monika Kulesza, Paweł Ławicki, Aleksandra Kicman, Emilia Łubińska, Sławomir Ławicki   +6 more
openaire   +3 more sources

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

TIS21에 의한 matrix metalloproteinases(MMPs) 발현 억제 연구

, 2014
Tetradecanoyl phorbol acetate-inducible sequence 21 (TIS21) is the mouse homolog of rat pheochromocytoma cell 3 (PC3) and human B-cell translocation gene 2 (BTG2).
최, 명호
core   +1 more source