Results 231 to 240 of about 246,934 (340)

A Pilot Serum Metabolomics Reveals Mitochondrial Dysfunction and Identifies Methylguanidine as a Potential Diagnostic Biomarker for ATAAD with Mesenteric Malperfusion Syndrome. [PDF]

Metabolites
Wen J, Zheng W, Sun L, Lu L, Lin Z, Chen L, Peng H, Wang Y.   +7 more
europepmc   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Plant-Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection. [PDF]

Basic Clin Pharmacol Toxicol
Dai J, Xia X, Hu X, Kanagaraj T, Rajalakshmi K, Deshpande M, Kiruthiga N, Zhu D, Fan Y.   +8 more
europepmc   +1 more source

Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs.

International Journal of Molecular Medicine, 2013
H. Yoon, Eun-Gyeong Lee, H. Lee, In Jin Cho, Yunjung Choi, Myung-Soon Sung, Han-Gyul Yoo, W. Yoo   +7 more
semanticscholar   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Classification, Structure-Activity Relationship, and Anti-Osteoarthritis Mechanism of Natural Flavonoids. [PDF]

Chem Biodivers
Wang H, Zheng S, Hua C, Feng W, Liu Z, Sun Y, Li M.   +6 more
europepmc   +1 more source

Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies.

Journal of Hepatology, 2007
S. Hemmann, J. Graf, M. Roderfeld, E. Roeb   +3 more
semanticscholar   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Histological features of <i>Jaculus jaculus</i> male-reproductive system: detection of metalloproteinases in testes and seminal vesicles during the active-reproductive phase. [PDF]

Anim Reprod
Zeghloul N, Lebaili-Benmoussa N, Ousmaal MEF, Lamine S, Gharnaout NL, Lekmine S, Moula N, Elfalleh W, Boufahja F, Bendif H, Tahraoui H, Amrane A.   +11 more
europepmc   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source