Results 61 to 70 of about 3,497,010 (299)
Applied SciencesThe use and importance of complex software-intensive systems are growing. As they are used in a wider range of situations in which dependability must be ensured, the reliability of the systems and of their components needs to be addressed throughout ...
Juan Manuel Morote +4 more
doaj +1 more source
Ontology and Model Based Systems Engineering
Procedia Computer Science, 2011 The subject of this paper is an information technology framework based on the use of an ontology that can be used for explicit and consistent specification, design, engineering, production and maintenance of complex facilities, e.g. ships and infrastructure.
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Leveraging Digital Twin Technology in Model-Based Systems Engineering
Systems, 2019 Digital twin, a concept introduced in 2002, is becoming increasingly relevant to systems engineering and, more specifically, to model-based system engineering (MBSE).
Azad M. Madni +2 more
doaj +1 more source
OntoEng: A design method for ontology engineering in information systems [PDF]
, 2009 This paper addresses the design problem relating to ontology engineering in the discipline of information systems. Ontology engineering is a realm that covers issues related to ontology development and use throughout its life span.
Al-Debei, MM, Fitzgerald, G
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Discovering the Impact of Knowledge in Recommender Systems: A Comparative Study [PDF]
, 2011 Recommender systems engage user profiles and appropriate filtering techniques to assist users in finding more relevant information over the large volume of information.
Amini, Bahram +2 more
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Engineering ProceedingsModel-based systems engineering (MBSE) offers significant advantages over traditional document-based approaches, particularly in improving the clarity, traceability, and efficiency of requirements engineering (RE).
Adrian Chojnacki +4 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source