Results 41 to 50 of about 151,713,479 (253)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
HIL TESTOVÁNÍ MECHTRONICKÉHO SYSTÉMU V LABORATORNÍCH PODMÍNKÁCH
Perner’s Contacts, 2018 Tento článek se zabývá laboratorním testováním snímačů a akčních členů u mechtronického systému určeného pro automatické uzavírání diferenciálu. Jeho řídicí algoritmus je implementován na hardware pro HIL testování.
Pavel Kučera, Václav Píštěk
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Loop is delighted and honoured to announce that poet and playwright Adam Wyeth, who lives and works in Dublin, is as of June 2024 a patron of Loop. We look forward to continuing our conversation with Adam, begun at the excellent 2024 SAES Congress at ...
The LOOP team
core +1 more source
Closed-loop control system for well-defined oxygen supply in micro-physiological systems
Current Directions in Biomedical Engineering, 2017 To improve cell vitality, sufficient oxygen supply is an important factor. A deficiency in oxygen is called Hypoxia and can influence for example tumor growth or inflammatory processes.
Steege Tobias +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
SystemsToday, the development of electrified commercial vehicles requires efficient validation methods that enable early system testing while maintaining consistency between development and testing models.
Manuel Mennicken +3 more
doaj +1 more source
Hardware in the Loop Simulation for Model Predictive Control Applied to Satellite Attitude Control
IEEE Access, 2019 Space systems are extremely complex and expensive robotic devices used in scientific, military and communication applications. Attitude control for aerospace systems is responsible for ensuring that the space object is in position, velocity and correct ...
Reurison Rodrigues +3 more
doaj +1 more source