Results 21 to 30 of about 441,526 (266)
A model of intracellular organization [PDF]
Proceedings of the National Academy of Sciences, 2005 Almost everything we know about biological chemistry comes from experiments on dilute samples of macromolecules (proteins, DNA, RNA, polysaccharides, etc.). By “dilute,” I mean macromolecular concentrations of 10 g per liter or less. Such conditions are astonishingly different from those inside living cells (1, 2).
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模式生物斑马鱼在卒中研究中的应用Application of Zebrafish Model Organism in Stroke Research
Zhongguo cuzhong zazhi, 2022 Animal model provides a necessary tool for exploring the complex pathophysiological process of cerebrovascular disease and drug development. Zebrafish (Danio rerio) is an ideal spinal model organism, which has the characteristics of small size, strong ...
莫东灿, 刘柳余, 李肖玲, 李建立, 罗曼
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Veterinary Sciences, 2017 Congenital heart defects, clinically identified in both small and large animals, are multifactorial and complex. Although heritable factors are known to have a role in cardiovascular disease, the full genetic aetiology remains unclear.
Jessica Vanderploeg, J. Roger Jacobs
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Frontiers in ImmunologyIntroductionThe new targeted gene editing technologies, such as the CRISPR/Cas system, enable researchers to insert or delete genes at targeted loci efficiently.
Yang Guo +7 more
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Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2016 Cancer therapy largely depends on chemotherapeutic agents that generate DNA lesions. However, our understanding of the nature of the resulting lesions as well as the mutational profiles of these chemotherapeutic agents is limited.
Annie S. Tam +2 more
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Metabolic network modeling with model organisms [PDF]
Current Opinion in Chemical Biology, 2017 Flux balance analysis (FBA) with genome-scale metabolic network models (GSMNM) allows systems level predictions of metabolism in a variety of organisms. Different types of predictions with different accuracy levels can be made depending on the applied experimental constraints ranging from measurement of exchange fluxes to the integration of gene ...
Yilmaz, L. Safak, Walhout, Albertha J M
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Microfluidic Devices in Advanced Caenorhabditis elegans Research
Molecules, 2016 The study of model organisms is very important in view of their potential for application to human therapeutic uses. One such model organism is the nematode worm, Caenorhabditis elegans. As a nematode, C.
Muniesh Muthaiyan Shanmugam +1 more
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Brain-Body Control of Glucose Homeostasis—Insights From Model Organisms
Frontiers in Endocrinology, 2021 Tight regulation of blood glucose is essential for long term health. Blood glucose levels are defended by the correct function of, and communication between, internal organs including the gastrointestinal tract, pancreas, liver, and brain.
Alastair J. MacDonald +4 more
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A future of the model organism model
Molecular Biology of the Cell, 2014 Changes in technology are fundamentally reframing our concept of what constitutes a model organism. Nevertheless, research advances in the more traditional model organisms have enabled fresh and exciting opportunities for young scientists to establish new careers and offer the hope of comprehensive understanding of fundamental processes in life.
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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