Results 101 to 110 of about 24,835,738 (277)

The antipsychotic drug sulpiride in the ventral pallidum paradoxically impairs learning and induces place preference

Scientific Reports, 2022
Sulpiride, as a D2-like dopamine (DA) receptor (D2R) antagonist, is an important antipsychotic drug in the treatment of schizophrenia. Recently, we have shown that the activation of D2Rs in the ventral pallidum (VP) modulates the activity of the ventral ...
Daniella Dusa, Tamás Ollmann, Veronika Kállai, László Lénárd, Erika Kertes, Beáta Berta, Ádám Szabó, Kristóf László, Rita Gálosi, Olga Zagoracz, Zoltán Karádi, László Péczely   +11 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Bridging Mechanistic and Phenomenological Models of Complex Biological Systems

, 2016
The inherent complexity of biological systems gives rise to complicated mechanistic models with a large number of parameters. On the other hand, the collective behavior of these systems can often be characterized by a relatively small number of ...
Qiu, Peng, Transtrum, Mark K.
core   +2 more sources

The Origin of Life: Models and Data. [PDF]

, 2017
A general framework for conventional models of the origin of life (OOL) is the specification of a 'privileged function.' A privileged function is an extant biological function that is excised from its biological context, elevated in importance over other
Lanier, Kathryn A, Williams, Loren Dean
core   +1 more source

Fermented beetroot modulates gut microbial carbohydrate metabolism in prediabetes and prevents high-fat diet induced hyperglycemia in a prediabetic model

Current Research in Food Science
The global increase in prevalence of (pre-)diabetes demands immediate intervention strategies. In our earlier work, we demonstrated in vitro antidiabetic potential of a fermented beetroot product (PN39).
Eric Banan-Mwine Daliri, Ashwinipriyadarshini Megur, Jonas Mingaila, Akshay Kumar Vijaya, Toma Balnionytė, Debalina Sakar, Yaiza Carnicero-Mayo, Volker Behrends, Adele Costabile, Aurelijus Burokas   +9 more
doaj   +1 more source

Rapid turnover of life-cycle-related genes in the brown algae

Genome Biology, 2019
Background Sexual life cycles in eukaryotes involve a cyclic alternation between haploid and diploid phases. While most animals possess a diploid life cycle, many plants and algae alternate between multicellular haploid (gametophyte) and diploid ...
Agnieszka P. Lipinska, Martha L. Serrano-Serrano, Alexandre Cormier, Akira F. Peters, Kazuhiro Kogame, J. Mark Cock, Susana M. Coelho   +6 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Standards for distribution models in biodiversity assessments

Science Advances, 2019
Biodiversity assessments use a variety of data and models. We propose best-practice standards for studies in these assessments. Demand for models in biodiversity assessments is rising, but which models are adequate for the task?
M. Araújo, M. Araújo, M. Araújo, R. Anderson, R. Anderson, R. Anderson, A. Barbosa, C. Beale, C. Dormann, R. Early, R. A. Garcia, A. Guisan, L. Maiorano, L. Maiorano, B. Naimi, R. O’Hara, N. Zimmermann, N. Zimmermann, C. Rahbek, C. Rahbek   +19 more
semanticscholar   +1 more source

Phenolic-rich lees from Philippine rice wine (tapuy) increases Caenorhabditis elegans lifespan in spite of having low antioxidant activity

Food Production, Processing and Nutrition
Tapuy is an indigenous wine produced in the Philippines. Rice wine fermentation produces a by-product of rice leftover and microbial biomass, collectively called lees, which usually is discarded as a waste product.
Sean Philippe L. Chua, Lesley Dale Umayat, Paul Mark B. Medina   +2 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source