Results 81 to 90 of about 3,547,769 (181)
Stability of a neural network model with small-world connections
, 2004 Small-world networks are highly clustered networks with small distances among the nodes. There are many biological neural networks that present this kind of connections.
C. Aguirre +15 more
core +1 more source
Molecules, 2016 The search for new molecular constructs that resemble the critical two-metal binding pharmacophore and the halo-substituted phenyl functionality required for HIV-1 integrase (IN) inhibition represents a vibrant area of research within drug discovery.
Guan-Nan Liu +7 more
doaj +1 more source
A novel dual DYRK1A/B inhibitor for the treatment of type 1 diabetes
Frontiers in PharmacologyBackgroundType 1 diabetes (T1D) is an autoimmune disease that leads to the progressive destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycemia. Current treatments focus on insulin replacement, but novel therapeutic approaches
Šarūnas Tumas +13 more
doaj +1 more source
Non-standard discretization of biological models [PDF]
, 2015 We consider certain types of discretization schemes for differential equations with quadratic nonlinearities, which were introduced by Kahan, and considered in a broader setting by Mickens.
Hone, Andrew N.W., Towler, Kim
core
MoleculesCannabis sativa L. is a plant that has been cultivated since ancient times thanks to its various uses. Even its extraction products, such as essential oil and hydrolate, having a varied chemical composition and rich in bioactive components, find wide use
Vittorio Vinciguerra +4 more
doaj +1 more source
Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria
Nature Communications, 2017 Carrageenans, major cell wall polysaccharides of red macroalgae, are metabolised by marine heterotrophic bacteria through unclear mechanisms. Here, the authors identify an unusual polysaccharide-utilization locus encoding carrageenan catabolism in a ...
Elizabeth Ficko-Blean +24 more
doaj +1 more source
Viruses, 2017 Experimental intranasal infection of marmosets (Callithrix jacchus) with calpox virus results in fatal disease. Route and dose used for viral inoculation of the test animals mimics the natural transmission of smallpox, thus representing a suitable model ...
Anne Schmitt +7 more
doaj +1 more source
Data-driven modelling of biological multi-scale processes
, 2015 Biological processes involve a variety of spatial and temporal scales. A holistic understanding of many biological processes therefore requires multi-scale models which capture the relevant properties on all these scales.
Hasenauer, Jan +3 more
core +1 more source
npj Regenerative MedicinePathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness.
Egidijus Simoliunas +20 more
doaj +1 more source
Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19
Signal Transduction and Targeted Therapy, 2020 Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment.
Hong-Yi Zheng +13 more
doaj +1 more source