Results 61 to 70 of about 26,569,710 (358)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Fostering computational thinking through educational robotics: a model for creative computational problem solving

International Journal of STEM Education, 2020
Educational robotics (ER) is increasingly used in classrooms to implement activities aimed at fostering the development of students’ computational thinking (CT) skills.
Morgane Chevalier, Christian Giang, Alberto Piatti, F. Mondada   +3 more
semanticscholar   +1 more source

Realization of situational cognitive models in English educational discourse

Вестник Самарского университета: История, педагогика, филология, 2022
The presented article is devoted to the study of the features of representation of situational models on the example of small-format English-language texts.
E. V. Yakovleva
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Using Multilevel Mixture Models in Educational Research: An Illustration with Homework Research

Journal of Experimental Education, 2019
The present study illustrates the utility of applying multilevel mixture models in educational research, using data on the homework behavior of 1,812 Swiss eighth-grade students in French as a second language.
Barbara Flunger, Ulrich Trautwein, B. Nagengast, O. Lüdtke, Alois Niggli, I. Schnyder   +5 more
semanticscholar   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The Choice between fixed and random effects models: some considerations for educational research. [PDF]

We discuss the use of fixed and random effects models in the context of educational research and set out the assumptions behind the two modelling approaches.
Paul Clarke, Fiona Steele, Claire Crawford, Anna Vignoles   +3 more
core   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Innovating education with an educational modelling language: two case studies [PDF]

Innovations in Education and Teaching International, 2006
The intent of this study was to investigate how to maximise the chances of success of an educational innovation—specifically one based on the implementation of the educational modelling language called EML. This language is both technically and organisationally demanding.
Sloep, Peter, Van Bruggen, Jan, Tattersall, Colin, Vogten, Hubert, Koper, Rob, Brouns, Francis; id_orcid 0000-0002-6240-2684, Van Rosmalen, Peter   +6 more
openaire   +2 more sources