Results 1 to 10 of about 25,100,395 (241)
A Genetic Model of the Connectome [PDF]
Neuron, 2020 The connectomes of organisms of the same species show remarkable architectural and often local wiring similarity, raising the question: where and how is neuronal connectivity encoded? Here, we start from the hypothesis that the genetic identity of neurons guides synapse and gap-junction formation and show that such genetically driven wiring predicts ...
Albert-László Barabási +3 more
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Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions [PDF]
Diabetes & Metabolism Journal, 2022 Diabetic peripheral neuropathy (DPN) affects over half of type 2 diabetes mellitus (T2DM) patients, with an urgent need for effective pharmacotherapies.
Md Jakir Hossain +4 more
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Frontiers in Endocrinology, 2023 ObjectiveTo investigate the efficacy of rituximab in the treatment of idiopathic membranous nephropathy (IMN).MethodsA total of 77 patients with IMN diagnosed in both our hospital and other hospitals were included in this study; the patients were divided
Ping Chen +15 more
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Genetic risks and genetic model specification [PDF]
Journal of Theoretical Biology, 2016 Genetic risks and genetic models are often used in design and analysis of genetic epidemiology studies. A genetic model is defined in terms of two genetic risk measures: genotype relative risk and odds ratio. The impacts of choosing a risk measure on the resulting genetic models are studied in the power to detect association and deviation from Hardy ...
Joseph L. Gastwirth +5 more
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Genetics in non-genetic model systems [PDF]
Current Opinion in Neurobiology, 2012 The past few decades have seen the field of genetic engineering evolve at a rapid pace, with neuroscientists now equipped with a wide range of tools for the manipulation of an animal's genome in order to study brain function. However, the number of species to which these technologies have been applied, namely the fruit fly, C.
Lois, Carlos, Groves, James O.
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A genetic programming approach to designing convolutional neural network architectures [PDF]
Annual Conference on Genetic and Evolutionary Computation, 2017 The convolutional neural network (CNN), which is one of the deep learning models, has seen much success in a variety of computer vision tasks. However, designing CNN architectures still requires expert knowledge and a lot of trial and error.
M. Suganuma, S. Shirakawa, T. Nagao
semanticscholar +1 more source
A MODEL FOR THE GENETICS OF HANDEDNESS [PDF]
Genetics, 1972 ABSTRACT Experimental data and theoretical work on the inheritance of handedness and cerebral dominance are reviewed. A two-gene, four-allele model, one locus pertaining to left or right hemispheric dominance and the other to contralateral or ipsilateral hand control relative to the dominant hemisphere, is constructed. It is in excellent
Jerre Levy, Thomas Nagylaki
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Multivariate Survival Mixed Models for Genetic Analysis of Longevity Traits [PDF]
, 2014 A class of multivariate mixed survival models for continuous and discrete time with a complex covariance structure is introduced in a context of quantitative genetic applications.
Labouriau, Rodrigo +2 more
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Cytoscape: a software environment for integrated models of biomolecular interaction networks.
Genome Research, 2003 Cytoscape is an open source software project for integrating biomolecular interaction networks with high-throughput expression data and other molecular states into a unified conceptual framework.
Paul Shannon +8 more
semanticscholar +1 more source
Genetic models of fibrillinopathies
GENETICS, 2023 Abstract The fibrillinopathies represent a group of diseases in which the 10–12 nm extracellular microfibrils are disrupted by genetic variants in one of the genes encoding fibrillin molecules, large glycoproteins of the extracellular matrix. The best-known fibrillinopathy is Marfan syndrome, an autosomal dominant condition affecting the
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