Results 1 to 10 of about 27,401,900 (294)
Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions [PDF]
Diabetes & Metabolism Journal, 2022 Diabetic peripheral neuropathy (DPN) affects over half of type 2 diabetes mellitus (T2DM) patients, with an urgent need for effective pharmacotherapies.
Md Jakir Hossain +4 more
doaj +1 more source
Genetic risks and genetic model specification [PDF]
Journal of Theoretical Biology, 2016 Genetic risks and genetic models are often used in design and analysis of genetic epidemiology studies. A genetic model is defined in terms of two genetic risk measures: genotype relative risk and odds ratio. The impacts of choosing a risk measure on the resulting genetic models are studied in the power to detect association and deviation from Hardy ...
Gang, Zheng +5 more
openaire +4 more sources
Genetics in non-genetic model systems [PDF]
Current Opinion in Neurobiology, 2012 The past few decades have seen the field of genetic engineering evolve at a rapid pace, with neuroscientists now equipped with a wide range of tools for the manipulation of an animal's genome in order to study brain function. However, the number of species to which these technologies have been applied, namely the fruit fly, C.
Lois, Carlos, Groves, James O.
openaire +3 more sources
, 2019 Genetically altered rat and mouse models have been instrumental in the functional analysis of genes in a physiological context. In particular, studies on the renin-angiotensin system (RAS) have profited from this technology in the past. In this review, we summarize the existing animal models for the protective axis of the RAS consisting of angiotensin ...
Alenina, Natalia, Bader, Michael
openaire +2 more sources
Frontiers in Endocrinology, 2023 ObjectiveTo investigate the efficacy of rituximab in the treatment of idiopathic membranous nephropathy (IMN).MethodsA total of 77 patients with IMN diagnosed in both our hospital and other hospitals were included in this study; the patients were divided
Ping Chen +15 more
doaj +1 more source
Cancer Cell, 2020 The development of precision medicine approaches for diffuse large B cell lymphoma (DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity. Recent multiplatform genomic studies revealed the existence of genetic subtypes of
George W. Wright +17 more
semanticscholar +1 more source
Multimodal deep learning models for early detection of Alzheimer’s disease stage
Scientific Reports, 2021 Most current Alzheimer’s disease (AD) and mild cognitive disorders (MCI) studies use single data modality to make predictions such as AD stages. The fusion of multiple data modalities can provide a holistic view of AD staging analysis.
Janani Venugopalan +3 more
semanticscholar +1 more source
Neuron, 2019 An individual's genetic makeup plays a large role in determining susceptibility to Alzheimer's disease (AD) but has largely been ignored in preclinical studies.
Sarah M. Neuner +4 more
semanticscholar +1 more source
A genetic programming approach to designing convolutional neural network architectures [PDF]
Annual Conference on Genetic and Evolutionary Computation, 2017 The convolutional neural network (CNN), which is one of the deep learning models, has seen much success in a variety of computer vision tasks. However, designing CNN architectures still requires expert knowledge and a lot of trial and error.
M. Suganuma, S. Shirakawa, T. Nagao
semanticscholar +1 more source
Genetic Models of Migraine [PDF]
Archives of Neurology, 2007 Migraine is a common, disabling, complex brain disorder, presenting in attacks that may have up to 3 phases: a prodromal phase, the aura phase, and the headache phase. The pathogenesis of the aura and headache phases is reasonably well understood, but the mechanism by which migraine attacks are triggered is unknown.
Rob C G, van de Ven +5 more
openaire +2 more sources