Results 101 to 110 of about 26,076,796 (269)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Identification of 1q25.2 as a novel shared locus between schizophrenia and major depressive disorder in east Asians by integrative analyses

Translational Psychiatry
Schizophrenia (SZ) and major depressive disorder (MDD) share psychopathological features, and their overlapped genetic architectures have been well-studied in Europeans.
Xiaoge Guo, Jinhua Huo, Peiling Shi, Luwen Zhang, Chuyi Zhang, Yongfeng Yang, Ming Li, Luxian Lv, Xiao Xiao, Wenqiang Li, Chuansheng Wang   +10 more
doaj   +1 more source

Predicting exchange rate volatility: genetic programming vs. GARCH and RiskMetrics [PDF]

This article investigates the use of genetic programming to forecast out-of-sample daily volatility in the foreign exchange market. Forecasting performance is evaluated relative to GARCH(1,1) and RiskMetrics models for two currencies, DEM and JPY ...
Christopher J. Neely, Paul A. Weller
core  

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

HSV-1 ICP22 condensates impair host transcription by depleting promoter RNAPII Ser-2P occupation

Frontiers in Microbiology
Herpes simplex virus type I (HSV-1) infection-induced host transcript ion shutdown is one of the most critical hallmarks of viral lytic infection. However, how HSV-1 and which viral factors accomplish this dramatic effect is not well understood.
Hansong Qi, Hansong Qi, Mengqiu Yin, Mengqiu Yin, Xiaoli Ren, Guijun Chen, Ai Li, Yongxia Li, Xia Cao, Jumin Zhou, Jumin Zhou   +10 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

YTHDF1/RNF7/p27 axis promotes prostate cancer progression

Cell Death and Disease
Prostate cancer (PCa) is a prevalent malignant tumor of the urinary system and remains the most common cancer among males. In this study, we showed that YTHDF1, one of the reader proteins involved in the N6-methyladenosine (m6A) modification signaling ...
Yulin Shi, Baiyang Liu, Yong Zhang, Sen Zhao, Li Zuo, Jun Pu, Haoqing Zhai, Dengcai Mu, Jia Du, Yan Cheng, Cuiping Yang, Yongbin Chen   +11 more
doaj   +1 more source

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2Research in context

EBioMedicine
Summary: Background: Coronavirus disease 2019 (COVID-19) is an immune-related disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The complete pathogenesis of the virus remains to be determined.
Ling Xu, Dandan Yu, Min Xu, Yamin Liu, Lu-Xiu Yang, Qing-Cui Zou, Xiao-Li Feng, Ming-Hua Li, Nengyin Sheng, Yong-Gang Yao   +9 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source