Results 111 to 120 of about 25,628,644 (319)

Unravelling spatial scale effects on elevational diversity gradients: insights from montane small mammals in Kenya

BMC Ecology and Evolution
Background Montane ecosystems play crucial roles as global biodiversity hotspots. However, climatic changes and anthropogenic pressure increasingly threaten the stability of montane community dynamics, such as diversity-elevation interactions, creating a
Kenneth Otieno Onditi, Noé U. de la Sancha, Simon Musila, Esther Kioko, Xuelong Jiang   +4 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

Nature Communications, 2017
Bacteria can be genetically engineered to kill specific pathogens or inhibit their virulence. We previously developed a synthetic genetic system that allows a laboratory strain of Escherichia coli to sense and kill Pseudomonas aeruginosa in vitro.
In Young Hwang, Elvin Koh, Adison Wong, J. March, W. Bentley, Yung Seng Lee, M. Chang   +6 more
semanticscholar   +1 more source

HSV-1 ICP22 condensates impair host transcription by depleting promoter RNAPII Ser-2P occupation

Frontiers in Microbiology
Herpes simplex virus type I (HSV-1) infection-induced host transcript ion shutdown is one of the most critical hallmarks of viral lytic infection. However, how HSV-1 and which viral factors accomplish this dramatic effect is not well understood.
Hansong Qi, Hansong Qi, Mengqiu Yin, Mengqiu Yin, Xiaoli Ren, Guijun Chen, Ai Li, Yongxia Li, Xia Cao, Jumin Zhou, Jumin Zhou   +10 more
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Genetically engineered mouse models in oncology research and cancer medicine

EMBO Molecular Medicine, 2016
Genetically engineered mouse models (GEMMs) have contributed significantly to the field of cancer research. In contrast to cancer cell inoculation models, GEMMs develop de novo tumors in a natural immune‐proficient microenvironment.
K. Kersten, K. D. de Visser, M. V. van Miltenburg, J. Jonkers   +3 more
semanticscholar   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

YTHDF1/RNF7/p27 axis promotes prostate cancer progression

Cell Death and Disease
Prostate cancer (PCa) is a prevalent malignant tumor of the urinary system and remains the most common cancer among males. In this study, we showed that YTHDF1, one of the reader proteins involved in the N6-methyladenosine (m6A) modification signaling ...
Yulin Shi, Baiyang Liu, Yong Zhang, Sen Zhao, Li Zuo, Jun Pu, Haoqing Zhai, Dengcai Mu, Jia Du, Yan Cheng, Cuiping Yang, Yongbin Chen   +11 more
doaj   +1 more source

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2Research in context

EBioMedicine
Summary: Background: Coronavirus disease 2019 (COVID-19) is an immune-related disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The complete pathogenesis of the virus remains to be determined.
Ling Xu, Dandan Yu, Min Xu, Yamin Liu, Lu-Xiu Yang, Qing-Cui Zou, Xiao-Li Feng, Ming-Hua Li, Nengyin Sheng, Yong-Gang Yao   +9 more
doaj   +1 more source