Results 31 to 40 of about 25,171,962 (340)
Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. [PDF]
, 2012 A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and ...
Belani, Chandra P +12 more
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Genetic model misspecification in genetic association studies [PDF]
BMC Research Notes, 2017 The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant model might be erroneously modelled as additive, an error investigated previously. We explored this question, for candidate gene studies, by evaluating the sample size required to compensate for ...
Amadou Gaye, Sharon K. Davis
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Genetic algorithms for the generation of models with micropopulations [PDF]
, 2003 Proceedings of: EvoWorkshops 2003: EvoBIO, EvoCOP, EvoIASP, EvoMUSART, EvoROB, and EvoSTIM Essex, UK, April 14–16, 2003The present article puts forward a method for an interactive model generation through the use of Genetic Algorithms applied to small ...
Isasi, Pedro +3 more
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Genetic models of focal epilepsies [PDF]
Journal of Neuroscience Methods, 2016 Focal epilepsies were for a long time thought to be acquired disorders secondary to cerebral lesions. However, the important role of genetic factors in focal epilepsies is now well established. Several focal epilepsy syndromes are now proven to be monogenic disorders.
Boillot, Morgane, Baulac, Stéphanie
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Genetic Models of Leukemia in Zebrafish [PDF]
Frontiers in Cell and Developmental Biology, 2018 The zebrafish animal model is gaining increasing popularity as a tool for studying human disease. Over the past 15 years, many models of leukemia and other hematological malignancies have been developed in the zebrafish. These confer some significant advantages over similar models in other animals and systems, representing a powerful resource for ...
Jeremy T. Baeten, Jill L. O. de Jong
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The Platelet as a Model for Chemical Genetics [PDF]
Chemistry & Biology, 2003 Chemical genetics is an emerging strategy in chemical biology that promises to bring the power of true genetics to mammalian systems and facilitate the transfer of biological discoveries to therapeutics. The platelet is an anucleate cell with several features that render it suitable for chemical genetic analysis.
Robert Flaumenhaft, Derek S. Sim
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The Neolithic transition in Europe: archaeological models and genetic evidence [PDF]
, 2003 The major pattern in the European gene pool is a southeast-northwest frequency gradient of classic genetic markers such as blood groups, which population geneticists initially attributed to the demographic impact of Neolithic farmers dispersing from the ...
Richards, Martin B.
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Genetic and environmental links between self-reports and parent-reports of child personality [PDF]
, 2018 Personality ratings have been consistently found to be reliable and moderately heritable, but interrater agreement between self- and other-report of personality are low-to-moderate, particularly in childhood samples. The current study aims to examine the
Savicki, Stephanie Louise
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Combining polynomial chaos expansions and genetic algorithm for the coupling of electrophysiological models [PDF]
, 2019 The number of computational models in cardiac research has grown over the last decades. Every year new models with di erent assumptions appear in the literature dealing with di erences in interspecies cardiac properties.
A Mahajan +17 more
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On Flexible finite polygenic models for multiple-trait evaluation [PDF]
, 2002 Finite polygenic models (FPM) might be an alternative to the infinitesimal model (TIM) for the genetic evaluation of pedigreed multiple-generation populations for multiple quantitative traits.
Bink, M.C.A.M.
core +2 more sources