Results 231 to 240 of about 3,334,982 (276)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Identity of Oxygen-Rich Nickel Oxides as Oxosuperoxides and Oxoperoxides and Their Heterostructures. [PDF]

Inorg Chem
Bujdák R, Derzsi M, Tokár K.
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Computational modelling of aggressive B-cell lymphoma. [PDF]

Biochem Soc Trans
Jayawant ES, Vareli A, Pepper A, Pepper C, Simoes F, Mitchell S.   +5 more
europepmc   +1 more source

Target-aware 3D molecular generation based on guided equivariant diffusion. [PDF]

Nat Commun
Hu Q, Sun C, He H, Xu J, Liu D, Zhang W, Shi S, Zhang K, Li H.   +8 more
europepmc   +1 more source

VitroBert: modeling DILI by pretraining BERT on in vitro data. [PDF]

J Cheminform
Masood MA, Nagaraja AA, Belaid K, Mesens N, Ceulemans H, Kaski S, Herman D, Heinonen M.   +7 more
europepmc   +1 more source

Special Issue "Molecules at Play in Neurological Diseases". [PDF]

Curr Issues Mol Biol
Iacobas DA.
europepmc   +1 more source