Results 11 to 20 of about 22,864,950 (290)
Neurorobotic Models of Neurological Disorders: A Mini Review
Frontiers in Neurorobotics, 2021 Modeling is widely used in biomedical research to gain insights into pathophysiology and treatment of neurological disorders but existing models, such as animal models and computational models, are limited in generalizability to humans and are restricted
Savva Pronin +5 more
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Companion animal models of neurological disease
Journal of Neuroscience Methods, 2020 Clinical translation of novel therapeutics that improve the survival and quality of life of patients with neurological disease remains a challenge, with many investigational drug and device candidates failing in advanced stage clinical trials. Naturally occurring inherited and acquired neurological diseases, such as epilepsy, inborn errors of ...
Brittanie Partridge, John H. Rossmeisl
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Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease
Molecules, 2020 Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with antidepressant, anxiolytic, anticonvulsant and antipsychotic effects ...
Serena Silvestro +3 more
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Construction of neural system disease models from the perspective of cellular biomechanics and their application in teaching practice [PDF]
Frontiers in Bioengineering and BiotechnologyBackgroundNeurological diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis present significant challenges to healthcare systems due to their complex pathophysiological mechanisms. Recent advancements in cellular biomechanics have opened new
Hong Xue +4 more
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Data-driven analyses of motor impairments in animal models of neurological disorders.
PLoS Biology, 2019 Behavior provides important insights into neuronal processes. For example, analysis of reaching movements can give a reliable indication of the degree of impairment in neurological disorders such as stroke, Parkinson disease, or Huntington disease.
Hardeep Ryait +11 more
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Animal Models of Neurological Disorders [PDF]
Neurotherapeutics, 2012 The discovery of new therapies for neurological disorders is predicated on the use of animal models both to identify new therapeutic targets and to perform preclinical trials of drugs before using them in patients. In both cases, the challenge is to develop models that recapitulate the disorder.
Marie-Francoise, Chesselet +1 more
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Oxford Open Neuroscience, 2023 The last decade has seen a dramatic rise in the number of genes linked to neurological disorders, necessitating new models to explore underlying mechanisms and to test potential therapies.
Harold A. Burgess, E. Burton
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Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease
International Journal of Molecular Sciences, 2023 Neurological diseases, including neurodegenerative and neurodevelopmental disorders, affect nearly one in six of the world’s population. The burden of the resulting deaths and disability is set to rise during the next few decades as a consequence of an ...
Victoria Chaoul +6 more
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The Translational Benefits of Sheep as Large Animal Models of Human Neurological Disorders
Frontiers in Veterinary Science, 2022 The past two decades have seen a considerable rise in the use of sheep to model human neurological disorders. While each animal model has its merits, sheep have many advantages over small animal models when it comes to studies on the brain. In particular,
Samantha J Murray, Nadia L. Mitchell
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Frontiers in Pharmacology, 2021 Cell cultures are used in pharmaceutical, medical and biological sciences. Due to the ethical and cost limitations of in vivo models, the replaceable cell model that is more closely related to the characteristics of organisms, which has broad prospects ...
Ye Peng +5 more
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