Results 11 to 20 of about 1,748,144 (308)

Isoprostanoids in Clinical and Experimental Neurological Disease Models [PDF]

Antioxidants, 2018
Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA. Although they were discovered about a quarter of century ago, the knowledge on the role of key isoprostanoids in the ...
Signorini, Cinzia, de Felice, Claudio, Galano, Jean-Marie, Oger, Camille, Leoncini, Silvia, Cortelazzo, Alessio, Ciccoli, Lucia, Durand, Thierry, Hayek, Joussef, Lee, Jetty   +9 more
openaire   +8 more sources

Porcine Models of Neurotrauma and Neurological Disorders

Biomedicines
The translation of therapeutics from lab to clinic has a dismal record in the fields of neurotrauma and neurological disorders [...]
John C. O’Donnell, Dmitriy Petrov
openaire   +4 more sources

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge, Thomas J. Tamsett, Christopher M. Treleaven, Tatyana V. Taksir, Peter Piepenhagen, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin   +7 more
doaj   +1 more source

Neurorobotic Models of Neurological Disorders: A Mini Review

Frontiers in Neurorobotics, 2021
Modeling is widely used in biomedical research to gain insights into pathophysiology and treatment of neurological disorders but existing models, such as animal models and computational models, are limited in generalizability to humans and are restricted
Savva Pronin, Savva Pronin, Liam Wellacott, Jhielson Pimentel, Renan C. Moioli, Patricia A. Vargas   +5 more
doaj   +1 more source

Unraveling pathological mechanisms in neurological disorders: the impact of cell-based and organoid models

Neural Regeneration Research, 2022
Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug therapies.
Jake Langlie, Rahul Mittal, Ariel Finberg, Nathalie B Bencie, Jeenu Mittal, Hossein Omidian, Yadollah Omidi, Adrien A Eshraghi   +7 more
doaj   +1 more source

Accuracy of transcranial magnetic stimulation and a Bayesian latent class model for diagnosis of spinal cord dysfunction in horses [PDF]

, 2020
Background: Spinal cord dysfunction/compression and ataxia are common in horses. Presumptive diagnosis is most commonly based on neurological examination and cervical radiography, but the interest into the diagnostic value of transcranial magnetic ...
Buczinski, Sebastien, Deprez, Piet, Dumoulin, Michèle, Pardon, Bart, Raes, Els, Rijckaert, Joke, Van Ham, Luc, van Loon, Gunther   +7 more
core   +1 more source

Animal Models of Neurological Disorders: Where Are We Now?

Biomedicines, 2023
The Special Issue “Animal Models of Neurological Disorders: Where Are We Now [...]
Sandesh Panthi, Marc Ekker
doaj   +1 more source

Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia

Dystonia, 2023
Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network.
Meike E. van der Heijden, Meike E. van der Heijden, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe   +6 more
doaj   +1 more source

Towards a Comprehensive Solution for a Vision-based Digitized Neurological Examination [PDF]

, 2022
The ability to use digitally recorded and quantified neurological exam information is important to help healthcare systems deliver better care, in-person and via telehealth, as they compensate for a growing shortage of neurologists. Current neurological digital biomarker pipelines, however, are narrowed down to a specific neurological exam component or
arxiv   +1 more source

Nurr1, Pitx3, and α7 nAChRs mRNA Expression in Nigral Tissue of Rats with Pedunculopontine Neurotoxic Lesion

Medicina, 2019
Background and Objectives: The knowledge that the cholinergic neurons from pedunculopontine nucleus (PPN) are vulnerable to the degeneration in early stages of the Parkinson disease progression has opened new perspectives to the development of ...
Lisette Blanco-Lezcano, Esteban Alberti-Amador, María Elena González-Fraguela, Guadalupe Zaldívar-Lelo de Larrea, Rosa Martha Pérez-Serrano, Nadia Angélica Jiménez-Luna, Teresa Serrano-Sánchez, Liliana Francis-Turner, Dianet Camejo-Rodriguez, Yamilé Vega-Hurtado   +9 more
doaj   +1 more source