Results 31 to 40 of about 522,540 (304)

Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models

Cells, 2022
Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades, yet the molecular mechanisms at the core of this damage remain largely unknown.
Abida Islam Pranty, Sara Shumka, James Adjaye   +2 more
doaj   +1 more source

Optogenetic cell control in experimental models of neurological disorders [PDF]

, 2013
The complexity of the brain, in which different neuronal cell types are interspersed and complexly interconnected, has posed a major obstacle in identifying pathophysiological mechanisms underlying prevalent neurological disorders.
Lund University., Tönnesen, Jan,
core   +3 more sources

Models of progressive neurological dysfunction originating early in life [PDF]

, 2017
It is now well established that many of society’s most devastating and costly neurological diseases and disorders arise from trauma at, or shortly after birth.
Marriott, Amber L., Rojas Mancilla, Edgardo, Herrera-Marschitz Muller, Mario, Tasker, R. Andrew, Morales Retamales, Paola   +4 more
core   +1 more source

Brain Organoids: Filling the Need for a Human Model of Neurological Disorder

Biology, 2021
Neurological disorders are among the leading causes of death worldwide, accounting for almost all onsets of dementia in the elderly, and are known to negatively affect motor ability, mental and cognitive performance, as well as overall wellbeing and ...
Philip Jalink, Massimiliano Caiazzo
doaj   +1 more source

Twenty years of health monitoring in a conventional neuroscience animal facility: challenges, strategies, and 3Rs-oriented approaches to animal welfare, personnel health, and research integrity

Frontiers in Physiology
Rodent health-monitoring programmes are essential for maintaining colony health, supporting health-related aspects of animal welfare and personnel biosafety, and providing relevant contextual information for the interpretation of experimental data ...
Daniele Peluso, Daniele Peluso, Paola Bonsi, Cecilia Gentile, Martina Montanari, Martina Montanari, Cesidio Romano, Cesidio Romano, Annarita Wirz   +8 more
doaj   +1 more source

Validation in Drosophila of the in silico predicted clomipramine as repurposable for SOD1-ALS

Neurotherapeutics
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration and muscle weakness, generally leading to death due to respiratory failure within 2–5 years of symptom onset.
Francesco Liguori, Susanna Amadio, Chiara Angioli, Angelo Ferriero, Iolanda Passaro, Francesca Alberti, Fiammetta Vernì, Cinzia Volonté   +7 more
doaj   +1 more source

Mouse models in neurological disorders: Applications of non-invasive imaging [PDF]

, 2010
Neuroimaging techniques represent powerful tools to assess disease-specific cellular, biochemical and molecular processes non-invasively in vivo. Besides providing precise anatomical localisation and quantification, the most exciting advantage of non ...
Waerzeggers, Yannic, Viel, Thomas, Jacobs, A., Winkeler, Alexandra, Winkeler, A., Jacobs, Andreas H., Waerzeggers, Y., Viel, T., Monfared, P., Monfared, Parisa   +9 more
core   +1 more source

Measuring disability in neurological rehabilitation : psychometric evaluation of two outcome measures. [PDF]

Objectives: To evaluate comprehensively the psychometric properties of the Functional Independence Measure (FIM) and the Functional Independence Measure + Functional Assessment Measure (FIM+FAM), and to compare their performance in stroke and ...
Hobart, Jeremy Charles
core   +1 more source

Experimental Animal Models in Neurological Diseases

Düzce Tıp Fakültesi Dergisi
The human brain is a structure that controls billions of neurons and trillions of connections. Having a unique anatomy with countless neurons and connections makes its understanding even more complex.
Neslihan Şirin, Şerif Demir
doaj   +1 more source

Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease

Molecules, 2020
Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with antidepressant, anxiolytic, anticonvulsant and antipsychotic effects ...
Serena Silvestro, Giovanni Schepici, Placido Bramanti, Emanuela Mazzon   +3 more
doaj   +1 more source