Results 51 to 60 of about 7,462,898 (307)
In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device
Micromachines, 2019 The blood−brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological disorders,
Jin-Ha Choi +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Non-Mammalian Models for Understanding Neurological Defects in RASopathies
BiomedicinesRASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders.
Mario Rodríguez-Martín +5 more
doaj +1 more source
A neurology-inspired model of web usage
Neurocomputing, 2014 The problem of predicting human behavior has been a great challenge for several disciplines including computer science. In particular, web user browsing behavior has been studied from the machine learning point of view, a field that has been coined web usage mining (WUM). However, current WUM techniques can be negatively impacted by changes in web site
Pablo E. Román, Juan D. Velásquez 0001
openaire +5 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Behavioral Sciences, 2018 Background: The degeneration of the pedunculopontine nucleus (PPN) precedes the degeneration of the nigral cells in the pre-symptomatic stages of Parkinson’s disease (PD).
Lisette Blanco-Lezcano +9 more
doaj +1 more source
Genome Biology, 2021 Background Many neurodegenerative diseases develop only later in life, when cells in the nervous system lose their structure or function. In many forms of neurodegenerative diseases, this late-onset phenomenon remains largely unexplained.
Matan Sorek +17 more
doaj +1 more source
Developing and validating a predictive model for stroke progression [PDF]
, 2011 <p><b>Background:</b> Progression is believed to be a common and important complication in acute stroke, and has been associated with increased mortality and morbidity.
O. Wu +9 more
core +1 more source
Early Treatment with Metformin Improves Neurological Outcomes in Lafora Disease
, 2022 Lafora disease is a fatal form of progressive myoclonic epilepsy caused by mutations in the EPM2A or NHLRC1/EPM2B genes that usually appears during adolescence.
María Machío-Castello +20 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source