Results 51 to 60 of about 839,668 (306)

Convolutional Neural Networks for Epileptic Seizure Prediction [PDF]

, 2018
Epilepsy is the most common neurological disorder and an accurate forecast of seizures would help to overcome the patient's uncertainty and helplessness.
Brinkmann, Benjamin, Eberlein, Matthias, Hildebrand, Raphael, Hoffmann, Nico, Kuhlmann, Levin, Müller, Jens, Tetzlaff, Ronald   +6 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Large Language Models in Neurological Practice: Real-World Study

Journal of Medical Internet Research
BackgroundLarge language models (LLMs) such as ChatGPT (OpenAI) and Gemini (Google) are increasingly explored for their potential in medical diagnostics, including neurology.
Natale Vincenzo Maiorana, Sara Marceglia, Mauro Treddenti, Mattia Tosi, Matteo Guidetti, Maria Francesca Creta, Tommaso Bocci, Serena Oliveri, Filippo Martinelli Boneschi, Alberto Priori   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila

Cell Death and Disease
Vitamin B6 is a water-soluble vitamin which possesses antioxidant properties. Its catalytically active form, pyridoxal 5’-phosphate (PLP), is a crucial cofactor for DNA and amino acid metabolism. The inverse correlation between vitamin B6 and cancer risk
Eleonora Pilesi, Giulia Tesoriere, Angelo Ferriero, Elisa Mascolo, Francesco Liguori, Luca Argirò, Chiara Angioli, Angela Tramonti, Roberto Contestabile, Cinzia Volontè, Fiammetta Vernì   +10 more
doaj   +1 more source

Flaviviruses—Induced Neurological Sequelae

Pathogens
Flaviviruses, a group of single-stranded RNA viruses spread by mosquitoes or ticks, include several significant neurotropic viruses, such as West Nile virus (WNV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Zika virus ...
Samantha Gabrielle Cody, Awadalkareem Adam, Andrei Siniavin, Sam S. Kang, Tian Wang   +4 more
doaj   +1 more source

Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. [PDF]

, 2018
ObjectiveInhibitors of the voltage-gated K+ channel Kv1.3 are currently in development as immunomodulators for the treatment of autoimmune diseases. As Kv1.3 is also expressed on microglia and has been shown to be specifically up-regulated on "M1-like ...
Azam, Beeton, Beschorner, Campanella, Chen, Chen, Chen, Courties, DeCoursey, Duque, Fadool, Fordyce, Fu, Gazula, Hu, Iadecola, Jacobs, Jin, Kaushal, Kawabori, Kettenmann, Khanna, Kundu-Raychaudhuri, Longa, Lyons, Macrez, Maezawa, Maezawa, Matheu, Meisel, Murray, Nguyen, Noraberg, Pannasch, Peng, Pennington, Pereira, Price, Rangaraju, Rangaraju, Rus, Ryck, Schlattmann, Schlichter, Schmitz, Tarcha, Tarcha, Wang, Wulff, Wulff   +49 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device

Micromachines, 2019
The blood−brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological disorders,
Jin-Ha Choi, Mallesh Santhosh, Jeong-Woo Choi   +2 more
doaj   +1 more source

Disrupted sleep in dystonia depends on cerebellar function but not motor symptoms in mice

Dystonia, 2023
Although dystonia is the third most common movement disorder, patients often also experience debilitating nonmotor defects including impaired sleep.
Luis E. Salazar Leon, Luis E. Salazar Leon, Luis E. Salazar Leon, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe   +7 more
doaj   +1 more source