Results 11 to 20 of about 518,429 (303)
Isoprostanoids in Clinical and Experimental Neurological Disease Models [PDF]
Antioxidants, 2018 Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA.
Cinzia Signorini +9 more
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Porcine Models of Neurotrauma and Neurological Disorders
BiomedicinesThe translation of therapeutics from lab to clinic has a dismal record in the fields of neurotrauma and neurological disorders [...]
John C. O’Donnell, Dmitriy Petrov
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Neurorobotic Models of Neurological Disorders: A Mini Review
Frontiers in Neurorobotics, 2021 Modeling is widely used in biomedical research to gain insights into pathophysiology and treatment of neurological disorders but existing models, such as animal models and computational models, are limited in generalizability to humans and are restricted
Savva Pronin +5 more
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Neural Regeneration Research, 2022 Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug therapies.
Jake Langlie +7 more
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Animal Models of Neurological Disorders: Where Are We Now?
Biomedicines, 2023 The Special Issue “Animal Models of Neurological Disorders: Where Are We Now [...]
Sandesh Panthi, Marc Ekker
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Mouse models for neurological disease
The Lancet Neurology, 2002 The mouse has many advantages over human beings for the study of genetics, including the unique property that genetic manipulation can be routinely carried out in the mouse genome. Most importantly, mice and human beings share the same mammalian genes, have many similar biochemical pathways, and have the same diseases.
Majid, Hafezparast +4 more
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In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device
Micromachines, 2019 The blood−brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological disorders,
Jin-Ha Choi +2 more
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Non-Mammalian Models for Understanding Neurological Defects in RASopathies
BiomedicinesRASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders.
Mario Rodríguez-Martín +5 more
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Alzheimer’s Research & Therapy, 2022 Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge +7 more
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Animal Models of Neurological Disorders [PDF]
Neurotherapeutics, 2012 The discovery of new therapies for neurological disorders is predicated on the use of animal models both to identify new therapeutic targets and to perform preclinical trials of drugs before using them in patients. In both cases, the challenge is to develop models that recapitulate the disorder.
Marie-Francoise, Chesselet +1 more
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