Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]
, 2013 Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Arai, Ken +13 more
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Viral-induced neurodegenerative disease. [PDF]
, 1999 Viral etiology has been postulated in a variety of neurological diseases in humans, including multiple sclerosis. Several experimental animal models of viral-induced neurodegenerative disease provide insight into potential host- and pathogen-dependent ...
Buchmeier, MJ, Lane, TE
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Comparison of different speech tasks among adults who stutter and adults who do not stutter
Clinics, 2016 OBJECTIVES: In this study, we compared the performance of both fluent speakers and people who stutter in three different speaking situations: monologue speech, oral reading and choral reading. This study follows the assumption that the neuromotor control
Ana Paula Ritto +3 more
doaj +1 more source
Incorporating neurological and behavioral mechanisms of sociality into predator-prey models
Frontiers in Behavioral Neuroscience, 2023 Consumer-resource population models drive progress in predicting and understanding predation. However, they are often built by averaging the foraging outcomes of individuals to estimate per capita functional responses (functions that describe predation ...
James L. L. Lichtenstein +2 more
doaj +1 more source
Clinical reasoning in canine spinal disease: what combination of clinical information is useful? [PDF]
, 2015 Spinal disease in dogs is commonly encountered in veterinary practice. Numerous diseases may cause similar clinical signs and presenting histories. The study objective was to use statistical models to identify combinations of discrete parameters from the
ABRAMSON +36 more
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Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury [PDF]
, 2017 Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE).
Acker, Christopher M. +11 more
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Companion animal models of neurological disease
Journal of Neuroscience Methods, 2020 Clinical translation of novel therapeutics that improve the survival and quality of life of patients with neurological disease remains a challenge, with many investigational drug and device candidates failing in advanced stage clinical trials. Naturally occurring inherited and acquired neurological diseases, such as epilepsy, inborn errors of ...
Brittanie Partridge, John H. Rossmeisl
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Modeling neurological diseases using iPSC-derived neural cells [PDF]
Cell and Tissue Research, 2017 Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases.
Li, Li, Jianfei, Chao, Yanhong, Shi
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Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models
Cells, 2022 Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades, yet the molecular mechanisms at the core of this damage remain largely unknown.
Abida Islam Pranty +2 more
doaj +1 more source
Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. [PDF]
, 2015 Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits.
Biswas, Sangita +5 more
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