Results 21 to 30 of about 22,864,950 (290)

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge, Thomas J. Tamsett, Christopher M. Treleaven, Tatyana V. Taksir, Peter Piepenhagen, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin   +7 more
doaj   +1 more source

Unraveling pathological mechanisms in neurological disorders: the impact of cell-based and organoid models

Neural Regeneration Research, 2022
Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug therapies.
Jake Langlie, Rahul Mittal, Ariel Finberg, Nathalie B Bencie, Jeenu Mittal, Hossein Omidian, Yadollah Omidi, Adrien A Eshraghi   +7 more
doaj   +1 more source

The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders

Frontiers in Psychiatry, 2020
Inflammation has been identified as one of the main pathophysiological mechanisms underlying neuropsychiatric and neurodegenerative disorders. Despite the role of inflammation in those conditions, there is still a lack of effective anti-inflammatory ...
J. Giacobbe, B. Benoiton, P. Zunszain, C. Pariante, A. Borsini   +4 more
semanticscholar   +1 more source

The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders.

Pharmacological Research, 2021
Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and the brain suggesting that gut microbes may shape neural development, modulate neurotransmission and affect behavior, and ...
K. Socała, U. Doboszewska, A. Szopa, A. Serefko, M. Włodarczyk, A. Zielińska, E. Poleszak, J. Fichna, P. Wlaź   +8 more
semanticscholar   +1 more source

Animal Models of Neurological Disorders: Where Are We Now?

Biomedicines, 2023
The Special Issue “Animal Models of Neurological Disorders: Where Are We Now [...]
Sandesh Panthi, Marc Ekker
doaj   +1 more source

Long-term, West Nile virus-induced neurological changes: A comparison of patients and rodent models

Brain, behavior, & immunity - health, 2020
West Nile virus (WNV) is a mosquito-borne virus that can cause severe neurological disease in those infected. Those surviving infection often present with long-lasting neurological changes that can severely impede their lives.
Corey Fulton, David W. C. Beasley, D. Bente, K. Dineley   +3 more
semanticscholar   +1 more source

Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia

Dystonia, 2023
Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network.
Meike E. van der Heijden, Meike E. van der Heijden, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe   +6 more
doaj   +1 more source

Computational Neurology: Computational Modeling Approaches in Dementia [PDF]

, 2021
Dementia is a collection of symptoms associated with impaired cognition and impedes everyday normal functioning. Dementia, with Alzheimer's disease constituting its most common type, is highly complex in terms of etiology and pathophysiology. A more quantitative or computational attitude towards dementia research, or more generally in neurology, is ...
Wong-Lin, KongFatt, Sanchez-Bornot, Jose M., McCombe, Niamh, Kaur, Daman, McClean, Paula L., Zou, Xin, Youssofzadeh, Vahab, Ding, Xuemei, Bucholc, Magda, Yang, Su, Prasad, Girijesh, Coyle, Damien, Maguire, Liam P., Wang, Haiying, Wang, Hui, Atiya, Nadim A.A., Joshi, Alok   +16 more
openaire   +3 more sources

Nurr1, Pitx3, and α7 nAChRs mRNA Expression in Nigral Tissue of Rats with Pedunculopontine Neurotoxic Lesion

Medicina, 2019
Background and Objectives: The knowledge that the cholinergic neurons from pedunculopontine nucleus (PPN) are vulnerable to the degeneration in early stages of the Parkinson disease progression has opened new perspectives to the development of ...
Lisette Blanco-Lezcano, Esteban Alberti-Amador, María Elena González-Fraguela, Guadalupe Zaldívar-Lelo de Larrea, Rosa Martha Pérez-Serrano, Nadia Angélica Jiménez-Luna, Teresa Serrano-Sánchez, Liliana Francis-Turner, Dianet Camejo-Rodriguez, Yamilé Vega-Hurtado   +9 more
doaj   +1 more source

CHANGING PERSPECTIVE ON PERCEPTION PHYSIOLOGY: CAN YOU REALLY SEE WHAT IS HAPPENING?

Euromediterranean Biomedical Journal, 2018
Perception is a complex, neural mechanism that requires organization and interpretation of input meaning and it has been a key topic in medicine, neuroscience and philosophy for centuries.
Giuseppe Giglia
doaj   +1 more source