Results 91 to 100 of about 766,195 (336)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Alexander Modules [PDF]

open access: yesProceedings of the American Mathematical Society, 1984
The Alexander modules of a link are the homology groups of the universal abelian cover of the complement of the link. For a link of n n -spheres in S n + 2 {S^{n + 2}} , we show that, if n ⩾ 2 n \geqslant 2
openaire   +2 more sources

Heterodyne Holography with full control of both signal and reference arms

open access: yes, 2015
Heterodyne holography is a variant of phase shifting holography in which reference and signal arms are controlled by acousto optic modulators. In this review paper, we will briefy describe the method and its properties, and we will illustrate its ...
Gross, Michel
core   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Crossed Modules

open access: yesNotices of the American Mathematical Society, 2023
This is an overview of the idea of a crossed module. For a group, the triple that consists of the group, its group of automorphisms, and the canonical homomorphism from the group to its group of automorphisms constitutes a crossed module. Crossed modules arise from the identities among the relations of the presentation of a group, from the extension ...
openaire   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Analysis of magnetically-controlled processes in pulse-modulation systems [PDF]

open access: yes, 1969
Investigation established analytic expressions for the design of pulse modulators with modulating signal control of the reset level of flux in a nonlinear magnetic core.
Veillette, L. J.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Use of natural rumen modulators to replace monensin plus virginiamycin in high-grain diets for cattle

open access: yesRevista de Ciências Agroveterinárias
This study aimed to evaluate food additives for the replacement of monensin and virginiamycin in high-grain diets for cattle. A Latin square experimental design was adopted, represented by four treatments (functional oil, yeast, tannin and control ...
Saulo Alberto do Carmo Araújo   +4 more
doaj   +1 more source

Waveguide Engineering of Graphene Optoelectronics—Modulators and Polarizers

open access: yesIEEE Photonics Journal, 2018
The concept of incorporating graphene into nanophotonic waveguides has pullulated into massive broadband optoelectronic applications with compact footprint.
Yuan Meng   +7 more
doaj   +1 more source

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