Principal factors that determine the extension of detection range in molecular beacon aptamer/conjugated polyelectrolyte bioassays. [PDF]
, 2015 A strategy to extend the detection range of weakly-binding targets is reported that takes advantage of fluorescence resonance energy transfer (FRET)-based bioassays based on molecular beacon aptamers (MBAs) and cationic conjugated polyelectrolytes (CPEs).
Bazan, Guillermo C +5 more
core +1 more source
Molecular Beacon Lighting up on Graphene Oxide [PDF]
, 2012 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry copyright © American Chemical Society after peer review and technical editing by publisher.
Huang, Po-Jung Jimmy, Liu, Juewen
core +1 more source
Chitosan Combined with Molecular Beacon for Mir-155 Detection and Imaging in Lung Cancer
Molecules, 2014 Lung cancer is the major cause of cancer-related deaths worldwide, thus developing effective methods for its early diagnosis is urgently needed. In recent years, microRNAs (miRNAs, miR) have been reported to play important roles in carcinogenesis and ...
Hai-Zhen Zhu +10 more
doaj +1 more source
Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics. [PDF]
, 2008 We demonstrate the first integrated microfluidic tmRNA purification and nucleic acid sequence-based amplification (NASBA) device incorporating real-time detection.
Antonio J. Ricco +48 more
core +1 more source
F1000Research, 2015 Microbes are now known to participate in an extensive repertoire of cooperative behaviors such as biofilm formation, production of extracellular public-goods, group motility, and higher-ordered multicellular structures.
Eric Bruger, Christopher Waters
doaj +1 more source
Techniques for RNA in vivo imaging in plants [PDF]
, 2014 Since the discovery of small RNAs and RNA silencing, RNA biology has taken a centre stage in cell and developmental biology. Small RNAs, but also mRNAs and other types of cellular and viral RNAs are processed at specific subcellular localizations.
Tilsner, Jens
core +1 more source
Emerging treatment options for BRAF-mutant colorectal cancer. [PDF]
, 2018 The personalization of cancer care is rooted in the premise that there are subsets of patients with tumors harboring clinically relevant targets for patient-specific treatments.
Atreya, Chloe E +2 more
core +2 more sources
Semiautomated Clone Verification by Real-Time PCR Using Molecular Beacons
BioTechniques, 2000 Conventional, high-throughput PCR analysis of common elements utilizing numerous primer sets and template DNA requires multiple rounds of PCR to ensure optimal conditions.
R.C.A.A. van Schie +5 more
doaj +1 more source
Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring. [PDF]
, 2019 The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously ...
Chen, Ching +17 more
core +1 more source
Evolution of linked avirulence effectors in Leptosphaeria maculans is affected by genomic environment and exposure to resistance genes in host plants [PDF]
, 2010 Brassica napus (canola) cultivars and isolates of the blackleg fungus, Leptosphaeria maculans interact in a ‘gene for gene’ manner whereby plant resistance (R) genes are complementary to pathogen avirulence (Avr) genes.
Brunner, P.C. +6 more
core +3 more sources