Results 71 to 80 of about 37,287 (222)
ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi +6 more
wiley +1 more source
Novel nano-biosensors for life science systems and their applications in early, accurate, and non-invasive melanoma and other types of cancer detection [PDF]
, 2007 Melanoma (the 5th and 6th most common cancer in Caucasian males and females, respectively), is the most severe form of skin cancer, which is often fatal if recognized in its advanced stage.
Bockrath, Marc +2 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin +7 more
wiley +1 more source
Biosensing using hairpin DNA probes
Reviews in Analytical Chemistry, 2015 Hairpin DNA probes (HDPs) are specially designed single-stranded DNA and have excellent sensing specificity. The past decade has witnessed the fast development of HDP-based biosensors due to the tremendous applications in biology, medicine, environmental
Huang Jiahao, Wu Jueqi, Li Zhigang
doaj +1 more source
The future of epilepsy care in the United Kingdom: A roadmap for technology‐enabled transformation
Epilepsia Open, EarlyView.Abstract Epilepsy is recognized to be a significant cause of premature mortality, socio‐economic distress and poor quality of life in economically developed countries. Despite clear clinical guidelines, epilepsy care is marked by delayed diagnosis, fragmented management, high emergency admission rates, and pronounced health inequalities affecting rural
John R. Terry, Rohit Shankar
wiley +1 more source
Electrochemistry Communications, 2019 We developed a one-step and label-free, electrochemical DNA detection method using metal ion-mediated molecular beacon (MB) probe specially designed to have target-specific sequence in its loop and Pb2+-binding aptamer in its stem.
Songyi Baek +4 more
doaj +1 more source
International Journal of Cancer, EarlyView.What's New? Patient‐derived organoids (PDOs) model tumor biology and drug response while preserving key tumor features, yet the impact of non‐genetic culture variables is poorly understood. This study examined the influence of organoid size, seeding density, and morphology on growth, drug sensitivity, and Wnt signaling in a colorectal cancer organoid ...
Viktoria Zieger +6 more
wiley +1 more source
Frontiers in Microbiology, 2019 We demonstrate that the antimicrobial peptide, melittin, is effective alone and in combination with the aminoglycosides tobramycin to kill Pseudomonas aeruginosa growing as biofilms both in vitro and in vivo.
Michael M. Maiden +4 more
doaj +1 more source
Two chemically distinct root lignin barriers control solute and water balance
Nature Communications, 2021 Defects in the Casparian strip, a fine band of lignin that seals root endodermal cells and plays roles in nutrient homeostasis, activate a signaling pathway leading to over-lignification.
Guilhem Reyt +15 more
doaj +1 more source
Observing Exoplanets with High-Dispersion Coronagraphy. II. Demonstration of an Active Single-Mode Fiber Injection Unit [PDF]
, 2017 High-dispersion coronagraphy (HDC) optimally combines high contrast imaging techniques such as adaptive optics/wavefront control plus coronagraphy to high spectral resolution spectroscopy.
Choquet, Elodie +14 more
core +3 more sources