Results 61 to 70 of about 37,287 (222)
Advanced Science, EarlyView.Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance +17 more
wiley +1 more source
Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley +1 more source
The Ambient Horn: Designing a novel audio-based learning experience [PDF]
, 2004 The Ambient Horn is a novel handheld device designed to support children learning about habitat distributions and interdependencies in an outdoor woodland environment.
Fitzpatrick, G +4 more
core +6 more sources
Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, EarlyView.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley +1 more source
Revealing Nucleic Acid Mutations Using Förster Resonance Energy Transfer-Based Probes
Sensors, 2016 Nucleic acid mutations are of tremendous importance in modern clinical work, biotechnology and in fundamental studies of nucleic acids. Therefore, rapid, cost-effective and reliable detection of mutations is an object of extensive research.
Nina P. L. Junager +2 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid +34 more
wiley +1 more source
Plant Protection Science, 2002 Control of SVBV relies completely on the use of virus-free planting material, that can be tested either by biological indexing or by molecular methods. A NASBA-based amplification was developed for the detection of SVBV.
D. Vašková, J. Špak
doaj +1 more source
Diversity of Lecidea (Lecideaceae, Ascomycota) species revealed by molecular data and morphological characters [PDF]
, 2002 The diversity of lichens, especially crustose species, in continental Antarctica is still poorly known. To overcome difficulties with the morphology based species delimitations in these groups, we employed molecular data (nuclear ITS and mitochondrial ...
Branson, K +20 more
core +2 more sources
The THESEUS Space Mission and the Infrared Telescope Calibration Unit
Astronomische Nachrichten, EarlyView.ABSTRACT The Transient High‐Energy Sky and Early Universe Surveyor (THESEUS) is an ESA M7 mission concept currently in Phase A, designed to exploit gamma‐ray bursts to probe the early Universe while advancing multi‐messenger and time‐domain astrophysics. To achieve its ambitious goals, THESEUS will combine wide‐band x‐ray and gamma‐ray monitors with an
András Péter Joó +9 more
wiley +1 more source