Results 51 to 60 of about 319,701 (282)
High Voltage, 2021 In this work, the air dielectric barrier discharge plasma was applied to a model of protein human serum albumin to explore plasma‐mediated protein damage from a biomolecular perspective.
Siqi Peng +6 more
doaj +1 more source
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]
, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T +13 more
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. [PDF]
, 2019 TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a ...
Han, Tina W +4 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Supramolecular Aggregates: Hardness Plus Softness
Molecules, 2021 The properties of supramolecular aggregates cross several disciplines, embracing the sciences of nature and joining theory, experiment, and application.
Lia Queiroz do Amaral
doaj +1 more source
A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. [PDF]
, 2019 The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged.
Caballero, Iracema +10 more
core +4 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Towards engineering and production of artificial spider silk using tools of synthetic biology
Engineering Biology, 2020 Spider silk is one of the strongest biomaterials available in nature. Its mechanical properties make it a good candidate for applications in various fields ranging from protective armour to bandages for wound dressing to coatings for medical implants ...
Hashwardhan Poddar +3 more
doaj +1 more source
Proof phenomenon as a function of the phenomenology of proving [PDF]
, 2015 Kurt Gödel wrote (1964, p. 272), after he had read Husserl, that the notion of objectivity raises a question: “the question of the objective existence of the objects of mathematical intuition (which, incidentally, is an exact replica of the question of ...
Hipólito, Inês
core +1 more source