Results 101 to 110 of about 227,395 (295)

Gymnastics of Molecular Chaperones [PDF]

Molecular Cell, 2010
Molecular chaperones assist folding processes and conformational changes in many proteins. In order to do so, they progress through complex conformational cycles themselves. In this review, I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and Hsp100 families.
openaire   +2 more sources

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Continuous-exchange cell-free protein synthesis using PCR-generated DNA and an RNase E-deficient extract

BioTechniques, 2008
Though the use of PCR-generated DNA (i.e., linear template) as template DNA is desirable because of its simple preparation, the linear template has not been routinely used in a conventional continuous-exchange cell-free (CECF) protein synthesis system ...
Soo Youn Jun, Sang Hyeon Kang, Kwang-Ho Lee   +2 more
doaj   +1 more source

Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU [PDF]

, 2002
Hsc66 and Hsc20 comprise a specialized chaperone system important for the assembly of iron-sulfur clusters in Escherchia coli. Only a single substrate, the Fe/S template protein IscU, has been identified for the Hsc66/Hsc20 system, but the mechanism by ...
Hoff, Kevin G., Silberg, Jonathan J., Ta, Dennis T., Tapley, Tim L., Vickery, Larry E.   +4 more
core   +1 more source

SnapShot: Molecular Chaperones, Part II

Cell, 2007
DnaK/1DKG; 1DKZ 69/monomer DnaJ, GrpE, ClpB Cytosol/folding of nascent proteins; export of some proteins; reactivates heat-inactivated proteins; facilitates abnormal protein degradation; works with ClpB in protein aggregate disassembly; regulates heat-shock response.Archaea Methanosarcinae DnaK 67/monomer DnaJ, GrpE Cytosol/similar to bacterial DnaK ...
Chang, H., Tang, Y., Hayer-Hartl, M., Hartl, F.   +3 more
openaire   +5 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Molecular Chaperones [PDF]

Biophysical Journal, 2008
Marissa V. Powers, Paul Workman
openaire   +2 more sources

Celastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens

Fundamental Research
Protein misfolding and aggregation are crucial pathogenic factors for cataracts, which are the leading cause of visual impairment worldwide. α-crystallin, as a small molecular chaperone, is involved in preventing protein misfolding and maintaining lens ...
Huaxia Wang, Qing Tian, Ying Zhang, Yibo Xi, Lidan Hu, Ke Yao, Jingyuan Li, Xiangjun Chen   +7 more
doaj   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

The chaperone DnaK promotes the emergence and accumulation of antibiotic-resistant clones through its ATPase activity in Riemerella anatipestifer

Poultry Science
The rapid emergence of antibiotic-resistant bacteria has become a global concern. In particular, the overuse of antibiotics in the breeding industry has accelerated the emergence of antibiotic-resistant bacteria, but the mechanisms driving this ...
Fang Guo, Chunfeng Shi, Li Huang, Yizhou Yao, Liping Qiao, Dekang Zhu, Mingshu Wang, Renyong Jia, Shun Chen, Xinxin Zhao, Ying Wu, Shaqiu Zhang, Ling Zhang, Yanling Yu, Friedrich Götz, Anchun Cheng, Mafeng Liu   +16 more
doaj   +1 more source