Results 121 to 130 of about 136,024 (249)

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer. [PDF]

Commun Med (Lond)
Heritz JA, Backe SJ, Pacherille A, Cayaban SJ, Basin MF, Smith B, Sager RA, Daneshvar M, Post DE, Woodford MR, Bourboulia D, Chisholm JD, Mollapour M, Bratslavsky G.   +13 more
europepmc   +1 more source

A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain. [PDF]

Protein Sci, 2023
Leppert A, Poska H, Landreh M, Abelein A, Chen G, Johansson J.   +5 more
europepmc   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source

New allosteric modulators of molecular chaperone TRAP1 from the integration of computational biology, medicinal chemistry, and biophysics. [PDF]

Cell Stress Chaperones
Guarra F, Komarov D, Ciamarone A, Torielli L, Previtali V, Margaroli N, Romeo E, La Spina M, Sbuelz F, Laquatra C, Veronesi M, Lolicato M, Arrigoni C, Moroni E, Serapian SA, Girotto S, Rasola A, Colombo G.   +17 more
europepmc   +1 more source

Deletion of Core 1 β3GalT-specific molecular chaperone (Cosmc) in murine intestinal epithelia leads to major alterations in glycocalyx and tumorigenesis. [PDF]

J Biol Chem
Ju T, Wang Y, Nishio H, Kudelka MR, Sun X, Wang J, Zeng J, Song L, Akkas G, Adsay V, Parkos CA, Cummings RD.   +11 more
europepmc   +1 more source

The Molecular Chaperone Mechanism of the C-Terminal Domain of Large-Size Subunit Catalases. [PDF]

Antioxidants (Basel), 2023
Nava-Ramírez T, Gutiérrez-Terrazas S, Hansberg W.   +2 more
europepmc   +1 more source

Molecular chaperone effects on recombinant yield and binding characteristics of an ABA-specific scFv in <i>Escherichia coli</i>. [PDF]

Front Bioeng Biotechnol
Chen S, Shan B, Luo Y, Mo G, Rasheed U, Lv L, Yang X, Lu Q.   +7 more
europepmc   +1 more source

Collagen-specific molecular chaperone Hsp47 in inguinal white adipose tissue promotes high-fat diet-induced inflammatory gene expression in male mice. [PDF]

Sci Rep
Ito S, Kamei R, Kasai A, Nagata K.
europepmc   +1 more source

The yeast molecular chaperone, Hsp104, influences transthyretin aggregate formation. [PDF]

Front Mol Neurosci, 2022
Knier AS, Davis EE, Buchholz HE, Dorweiler JE, Flannagan LE, Manogaran AL.   +5 more
europepmc   +1 more source