Results 171 to 180 of about 225,633 (278)

Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni, Prince Kumar Singh, Sereen Sandouka, Taige Zhang, Alina Nemirovski, Aseel Saadi, Rhoda Olowe Taiwo, Matthew C. Walker, Tawfeeq Shekh‐Ahmad   +8 more
wiley   +1 more source

Thyroidal expression of ER molecular chaperone GRP170 is required for efficient TSH-mediated thyroid hormone synthesis. [PDF]

JCI Insight
Zhang X, Young C, Liao XH, Refetoff S, Mutchler SM, Brodsky JL, Buck TM, Arvan P.   +7 more
europepmc   +1 more source

Computational Analysis of the Ligand-Binding Sites of the Molecular Chaperone OppA from Yersinia pseudotuberculosis. [PDF]

Int J Mol Sci, 2023
Ramírez MB, Urzúa LS, Martínez MLÁM, Morales LJM.   +3 more
europepmc   +1 more source

Consecutive Steps of Nucleoside Triphosphate Hydrolysis Are Driving Transport of Precursor Proteins into the Endoplasmic Reticulum [PDF]

, 1992
Klappa, Peter, Lill, Roland, Müller, Günter, Neupert, Walter, Schlenstedt, Gabriel, Wiech, Hans, Zimmermann, Richard   +6 more
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Single-molecule study of the dynamics of the molecular chaperone Hsp70 during the functional cycle. [PDF]

Biochem Soc Trans
Hu H, Yang M, Perrett S, Wu S.
europepmc   +1 more source

The cold atmospheric pressure plasma-generated species superoxide, singlet oxygen and atomic oxygen activate the molecular chaperone Hsp33. [PDF]

J R Soc Interface, 2023
Dirks T, Krewing M, Vogel K, Bandow JE.
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

The Molecular Chaperone TCP1 Affects Carcinogenicity and Is a Potential Therapeutic Target for Acute Myeloid Leukemia. [PDF]

Pharmaceutics
Wu Y, Tu G, Yuan Y, Liu J, Jiang Q, Liu Y, Wu Q, Wu L, Chen Y.   +8 more
europepmc   +1 more source

ATP-independent molecular chaperone activity generated under reducing conditions. [PDF]

Protein Sci, 2022
Leppert A, Chen G, Lianoudaki D, Williams C, Zhong X, Gilthorpe JD, Landreh M, Johansson J.   +7 more
europepmc   +1 more source