Results 11 to 20 of about 225,633 (278)

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
R. A. Spooner, P. J. Hart, J. P. Cook, P. Pietroni, C. Rogon, J. Hohfeld, L. M. Roberts, J. M. Lord, Brodsky, Meusser, Spooner, Wesche, Argent, van Deurs, Rapak, Wales, Meacham, Brodsky, Hudson, Roe, Lawson, Argent, Savino, Chaddock, Chen, Luders, H  hfeld, Urushitani, Younger, Arndt, Nakatsukasa, Nakatsukasa, Hundley   +32 more
core   +4 more sources

Molecular Chaperone Receptors [PDF]

, 2017
Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors expressed on a wide range of cell types. We have investigated the nature of such proteins by cloning candidate receptors into cells (CHO-K1) with the rare property of being null for HSP binding. Using this
Ayesha, Murshid, Jimmy, Theriault, Jianlin, Gong, Stuart K, Calderwood   +3 more
openaire   +2 more sources

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

Frontiers in Cell and Developmental Biology, 2020
Molecular chaperones are critical to maintaining intracellular proteostasis and have been shown to have a protective role against alpha-synuclein-mediated toxicity.
Erik L. Friesen, Erik L. Friesen, Yu Tong Zhang, Yu Tong Zhang, Rebecca Earnshaw, Rebecca Earnshaw, Mitch L. De Snoo, Mitch L. De Snoo, Darren M. O’Hara, Darren M. O’Hara, Victoria Agapova, Hien Chau, Sophie Ngana, Sophie Ngana, Kevin S. Chen, Kevin S. Chen, Lorraine V. Kalia, Lorraine V. Kalia, Lorraine V. Kalia, Suneil K. Kalia, Suneil K. Kalia, Suneil K. Kalia   +21 more
doaj   +1 more source

Small heat-shock proteins: important players in regulating cellular proteostasis [PDF]

, 2015
Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection.
Carver, John A., Ecroyd, Heath, Meehan, Sarah, Treweek, Teresa M.   +3 more
core   +1 more source

Role of Subunit Exchange and Electrostatic Interactions on the Chaperone Activity of Mycobacterium leprae HSP18. [PDF]

PLoS ONE, 2015
Mycobacterium leprae HSP18, a major immunodominant antigen of M. leprae pathogen, is a small heat shock protein. Previously, we reported that HSP18 is a molecular chaperone that prevents aggregation of different chemically and thermally stressed client ...
Sandip Kumar Nandi, Alok Kumar Panda, Ayon Chakraborty, Sougata Sinha Ray, Ashis Biswas   +4 more
doaj   +1 more source

Structural Bioinformatics and Protein Docking Analysis of the Molecular Chaperone-Kinase Interactions: Towards Allosteric Inhibition of Protein Kinases by Targeting the Hsp90-Cdc37 Chaperone Machinery

Pharmaceuticals, 2013
A fundamental role of the Hsp90-Cdc37 chaperone system in mediating maturation of protein kinase clients and supporting kinase functional activity is essential for the integrity and viability of signaling pathways involved in cell cycle control and ...
Gennady Verkhivker, Elizabeth Berrigan, Nathan Lawless, Kristin Blacklock   +3 more
doaj   +1 more source

αA-Crystallin-derived mini-chaperone modulates stability and function of cataract causing αAG98R-crystallin. [PDF]

PLoS ONE, 2012
A substitution mutation in human αA-crystallin (αAG98R) is associated with autosomal dominant cataract. The recombinant mutant αAG98R protein exhibits altered structure, substrate-dependent chaperone activity, impaired oligomer stability and aggregation ...
Murugesan Raju, Puttur Santhoshkumar, K Krishna Sharma   +2 more
doaj   +1 more source

Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry [PDF]

, 2008
P pili are multisubunit fibers essential for the attachment of uropathogenic Escherichia coli to the kidney. These fibers are formed by the noncovalent assembly of six different homologous subunit types in an array that is strictly defined in terms of ...
A. E. Ashcroft, Benesch, Choudhury, D. Verger, Dodson, E. Paci, G. Waksman, Gong, H. Remaut, Jacob-Dubuisson, Jacob-Dubuisson, Jones, R. J. Rose, Remaut, Remaut, Roberts, Rose, S. E. Radford, Sauer, Sauer, Sauer, Saulino, Soto, Stathopoulos, T. Daviter, Thanassi, Thanassi, Verger, Zavialov   +28 more
core   +2 more sources

Functions and Therapeutic Potential of Extracellular Hsp60, Hsp70, and Hsp90 in Neuroinflammatory Disorders

Applied Sciences, 2021
Neuroinflammation is implicated in central nervous system (CNS) diseases, but the molecular mechanisms involved are poorly understood. Progress may be accelerated by developing a comprehensive view of the pathogenesis of CNS disorders, including the ...
Giusi Alberti, Letizia Paladino, Alessandra Maria Vitale, Celeste Caruso Bavisotto, Everly Conway de Macario, Claudia Campanella, Alberto J. L. Macario, Antonella Marino Gammazza   +7 more
doaj   +1 more source

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
A. Tzagoloff, A. Tzagoloff, A.J. Caplan, A.J. Caplan, B.D. Gambill, B.S. Glick, C.K. Suzuki, D. Ang, D. M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.P. Atencio, E. Ikeda, E. Kutejová, E.A. Craig, E.A. Craig, F.-U. Hartl, G.S.P. Groot, H.R.B. Pelham, J. Ostermann, J. Rassow, J.F. Dice, J.P. Hendrick, K. Liberek, L. Dyck van, M. Eilers, M. Kiebler, M. Schleyer, M.-J. Gething, M.Y. Cheng, N. Rowley, N. Wang, P. Borst, P. Terpstra, P.-J. Kang, R. A. Stuart, R.A. Stuart, R.A. Stuart, R.B. Deshaies, R.G. Hadikusumo, R.J. Nelson, R.P. Beckman, S. Lindquist, S. Rospert, S.T. Hwang, T. Langer, U.C. Manning-Krieg, W. Neupert, W. Neupert, W. Voos, W.J. Chirico, Z. Xia   +53 more
core   +1 more source