Results 71 to 80 of about 5,665,898 (300)

Selection of endometrial carcinomas for p53 immunohistochemistry based on nuclear features

The Journal of Pathology: Clinical Research, 2022
The World Health Organization endorses molecular subclassification of endometrial endometrioid carcinomas (EECs). Our objectives were to test the sensitivity of tumor morphology in capturing p53 abnormal (p53abn) cases and to model the impact of p53abn ...
Eun Young Kang, Nicholas JP Wiebe, Christa Aubrey, Cheng‐Han Lee, Michael S Anglesio, Derek Tilley, Prafull Ghatage, Gregg S Nelson, Sandra Lee, Martin Köbel   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Classification of molecular sequence data using Bayesian phylogenetic mixture models [PDF]

, 2014
Rate variation among the sites of a molecular sequence is commonly found in applications of phylogenetic inference. Several approaches exist to account for this feature but they do not usually enable the investigator to pinpoint the sites that evolve ...
Robinson, A., Hurn, M. A., Loza Reyes, E., Loza-Reyes, E.   +3 more
core   +1 more source

Molecular Classification in Patients With Endometrial Cancer After Fertility-Preserving Treatment: Application of ProMisE Classifier and Combination of Prognostic Evidence

Frontiers in Oncology, 2022
The Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) is a molecular classification system that identifies endometrial cancer (EC) into four prognostically distinct subtypes: POLE-mutated, mismatch repair deficiency (MMR-D), p53 wild ...
Xuting Ran, Xuting Ran, Tingwenyi Hu, Tingwenyi Hu, Zhengyu Li, Zhengyu Li   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A consensus molecular classification of muscle-invasive bladder cancer [PDF]

, 2020
Background: Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes their clinical application ...
Dinney, Colin P, Real, Francisco X., Castro, Mauro A A, Kim, William Y, Real, Francisco X, Choi, Woonyoung, Bellmunt, Joaquim, Groeneveld, Clarice S, Lerner, Seth P., Hoadley, Katherine A, Hoadley, Katherine A., Real Arribas, Francisco, Dinney, Colin P., Powles, Thomas, Malats, Núria, Zlotta, Alexandre, Hartmann, Arndt, Seiler, Roland, Robertson, A Gordon, Al-Ahmadie, Hikmat, Radvanyi, François, Groeneveld, Clarice S., Fontugne, Jacqueline, Chan, Keith S., McConkey, David J, Allory, Yves, de Reyniès, Aurélien, Chan, Keith S, Kim, William Y., Dyrskjøt, Lars, Black, Peter C, Lerner, Seth P, Kamoun, Aurélie, Reyniès, Aurélien de, Höglund, Mattias, Bladder Cancer Molecular Taxonomy Group, Sjödahl, Gottfrid, Mo, Qianxing, Black, Peter C., McConkey, David J., Castro, Mauro A.A., Eriksson, Pontus, Gordon Robertson, A., Kardos, Jordan   +43 more
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Molecular Classification of Hepatocellular Adenomas [PDF]

International Journal of Hepatology, 2013
Hepatocellular adenomas (HCAs) are benign tumors developed in normal liver most frequently in women before menopause. HCAs lead to diagnostic pitfalls and several difficulties to assess the risk of malignant transformation in these young patients.
Jean Charles Nault, Jessica Zucman Rossi
openaire   +3 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source