Results 81 to 90 of about 5,665,898 (300)

Anatomical, histomorphological and molecular classification of cholangiocarcinoma [PDF]

Liver International, 2019
AbstractCholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at any point of the biliary tree. Cholangiocarcinoma is classified into intrahepatic, perihilar and distal based on its anatomical location. Histologically, conventional perihilar/distal cholangiocarcinomas are mucin‐producing adenocarcinomas or papillary ...
Kendall T., Verheij J., Gaudio E., Evert M., Guido M., Goeppert B., Carpino G.   +6 more
openaire   +2 more sources

J-PMCRI: a methodology for inducing pre-pruned modular classification rules [PDF]

, 2010
Inducing rules from very large datasets is one of the most challenging areas in data mining. Several approaches exist to scaling up classification rule induction to large datasets, namely data reduction and the parallelisation of classification rule ...
Frederic Stahl, Stahl, F., Stahl, Frederic, Bramer, Max, Mo Adda, Bramer, M., Max Bramer, Adda, Mo, Adda, M.   +8 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

ISSVA Classification of Vascular Anomalies and Molecular Biology

, 2022
Vascular anomalies include various diseases, which are classified into two types according to the International Society for the Study of Vascular Anomalies (ISSVA) classification: vascular tumors with proliferative changes of endothelial cells, and ...
Kayo Kunimoto, Yuki Yamamoto, Masatoshi Jinnin   +2 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Molecular pathological classification of colorectal cancer [PDF]

Virchows Archiv, 2016
Colorectal cancer (CRC) shows variable underlying molecular changes with two major mechanisms of genetic instability: chromosomal instability and microsatellite instability. This review aims to delineate the different pathways of colorectal carcinogenesis and provide an overview of the most recent advances in molecular pathological classification ...
Müller, Mike-Freya, Ibrahim, Ashraf Ek, Arends, Mark; id_orcid 0000-0002-6826-8770   +2 more
openaire   +3 more sources

Improving classification in protein structure databases using text mining [PDF]

, 2009
Background: The classification of protein domains in the CATH resource is primarily based on structural comparisons, sequence similarity and manual analysis.
Jones, DT, Koussounadis, A, Oliver C Redfern, Redfern, Oliver, Koussounadis Antonis, Jones David T, Redfern, OC, Redfern Oliver C, Antonis Koussounadis, David T Jones, Jones, David, Koussounadis, Antonis   +11 more
core   +1 more source

Precision oncology in gynecologic cancers: molecular taxonomy, biomarker-guided therapeutics, and the challenge of therapeutic resistance

Frontiers in Oncology
IntroductionThe clinical management of gynecologic malignancies endometrial (EC), ovarian (OC), and cervical (CC) carcinomas has been historically guided by histomorphology and staging.
Shanza Waseem, Shanza Waseem, Shanza Waseem, Shanza Waseem, Jun Zhan, Jun Zhan, Jun Zhan, Jun Zhan, Xue Xiao, Xue Xiao, Xue Xiao, Xue Xiao, Peng Bai   +12 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition

OncoImmunology, 2017
High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced immune response in highly mutated ECs and to explore immune profiles in other EC subgroups.
Florine A. Eggink, Inge C. Van Gool, Alexandra Leary, Pamela M. Pollock, Emma J. Crosbie, Linda Mileshkin, Ekaterina S. Jordanova, Julien Adam, Luke Freeman-Mills, David N. Church, Carien L. Creutzberg, Marco De Bruyn, Hans W. Nijman, Tjalling Bosse   +13 more
doaj   +1 more source