Results 111 to 120 of about 4,904,917 (369)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

VAMP721 conformations unmask an extended motif for K+ channel binding and gating control [PDF]

, 2016
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins play a major role in membrane fusion and contribute to cell expansion, signaling, and polar growth in plants.
Blatt, Mike R., Donald, Naomi Alice, Karnik, Rucha, Waghmare, Sakharam, Zhang, Ben   +4 more
core   +2 more sources

Complete maps of molecular‐loop conformational spaces [PDF]

Journal of Computational Chemistry, 2007
AbstractThis paper presents a numerical method to compute all possible conformations of distance‐constrained molecular loops, i.e., loops where some interatomic distances are held fixed, while others can vary. The method is general (it can be applied to single or multiple intermingled loops of arbitrary topology) and complete (it isolates all solutions,
Porta Pleite, Josep Maria, Ros Giralt, Lluís, Thomas, Federico, Corcho Sánchez, Francisco José, Cantó Silva, Josep, Pérez, Juan J.   +5 more
openaire   +6 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

$\alpha$- and $\beta$- Relaxation Dynamics of a fragile plastic crystal

, 2006
We present a thorough dielectric investigation of the relaxation dynamics of plastic crystalline Freon112, which exhibits freezing of the orientational degrees of freedom into a glassy crystal below 90 K. Among other plastic crystals, Freon112 stands out
Loidl, A., Lunkenheimer, P., Pardo, L. C.   +2 more
core   +1 more source

Substitutions in the redox-sensing PAS domain of the NifL regulatory protein define an inter-subunit pathway for redox signal transmission [PDF]

, 2011
The Per-ARNT-Sim (PAS) domain is a conserved a/ß fold present within a plethora of signalling proteins from all kingdoms of life. PAS domains are often dimeric and act as versatile sensory and interaction modules to propagate environmental signals to ...
Ayers, Campbell, Demeler, Dixon, Hefti, Hill, Karimova, Key, Kurokawa, Little, Little, Little, Ma, Macheroux, Martinez-Argudo, Matthews, Miyatake, Money, Möglich, Möglich, Möglich, Nan, Perry, Qi, Reyes-Ramirez, Reyes-Ramirez, Slavny, Söderbäck, Taylor, Ukaegbu, Watts, Williamson, Zhou, Zoltowski, Zoltowski   +34 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Molecular Properties of Water-Unextractable Proteoglycans from Hypsizygus marmoreus and Their in Vitro Immunomodulatory Activities

Molecules, 2011
Four proteoglycans were sequentially extracted from Hypsizygus marmoreus using 0.1 M NaOH (alkali-soluble proteoglycans [F1] and alkali-insoluble proteoglycans [F3]) and 0.1 M HCl (acid-soluble proteoglycans [F2] and acid-insoluble proteoglycans [F4 ...
Hee Mun Chae, Hong Hui Bao, Mehdi Tarbasa, Sang Guan You   +3 more
doaj   +1 more source

Molecular and crystal structure, lattice energy and DFT calculations of two 2′-(nitrobenzoyloxy)acetophenone isomers

Acta Crystallographica Section E: Crystallographic Communications, 2020
The two isomers 2′-(4-nitrobenzoyloxy)acetophenone (systematic name: 2-acetylphenyl 4-nitrobenzoate) (I) and 2′-(2-nitrobenzoyloxy)acetophenone (systematic name: 2-acetylphenyl 2-nitrobenzoate) (II), both C15H11NO5, with para and ortho positions of the ...
Georgii Bogdanov, Jenna Bustos, Viktor Glebov, Evgenii Oskolkov, John P. Tillotson, Tatiana V. Timofeeva   +5 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source