Results 61 to 70 of about 634,211 (283)

Molecular techniques for cancer diagnostics

Academia Medicine
Cancer cells differ from healthy tissues in their biological makeup. Recent research reported vast genetic and epigenetic heterogeneity, differences in the gene-expression profiles, and signal transduction networks in a broad range of cancers. These discoveries led to the development and clinical approval of several drugs that are more efficient and ...
Vimal Kishor Singh, Ramesh Chandra
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Vaccination With a Gamma Irradiation-Inactivated African Swine Fever Virus Is Safe But Does Not Protect Against a Challenge

Frontiers in Immunology, 2022
African swine fever (ASF) is among the most devastating viral diseases of pigs and wild boar worldwide. In recent years, the disease has spread alarmingly.
Jutta Pikalo, Luca Porfiri, Valerij Akimkin, Hanna Roszyk, Katrin Pannhorst, Richard Thiga Kangethe, Viskam Wijewardana, Julia Sehl-Ewert, Martin Beer, Giovanni Cattoli, Sandra Blome   +10 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Molecular techniques for clinical diagnostic bacteriology

Turkish Bulletin of Hygiene and Experimental Biology, 2015
Moleküler yöntemler enfeksiyon hastalıkların patogenezinin ve epidemiyolojisinin anlaşılmasında çok önemli katkıda bulunmuştur. Polimeraz zincir reaksiyonu (PZR), en yaygın kullanılan hedef nükleik asit amplifikasyon yöntemidir. Bu yöntem ile tek bir nükleik asidin kopyası çok kısa bir süre içinde 107 kereden fazla çoğalır.
openaire   +3 more sources

Focal Spot, Winter 2006/2007 [PDF]

, 2007
https://digitalcommons.wustl.edu/focal_spot_archives/1104/thumbnail ...

core   +1 more source

Multiplex ligation-dependent probe amplification (MLPA) analysis is an effective tool for the detection of novel intragenic PLA2G6 mutations: Implications for molecular diagnosis [PDF]

, 2010
Phospholipase associated neurodegeneration (PLAN) comprises a heterogeneous group of autosomal recessive neurological disorders caused by mutations in the PLA2G6 gene. Direct gene sequencing detects 85% mutations in infantile neuroaxonal dystrophy.
Brady, Angela F, Crompton, Danielle, De Gressi, Susanna, Foster, Kathleen, Hardy, Carol, Hughes, Imelda, Kurian, Manju A, Lunt, Peter, MacPherson, Lesley, Maher, Eamonn R, McDonald, Fiona, Morgan, Neil V, Pike, Michael G, Rehal, Pauline K, Smith, Matthew   +14 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

From phenotypic to molecular diagnosis: Insights from a clinical immunology service focused on inborn errors of immunity in Colombia

Biomédica: revista del Instituto Nacional de Salud
Introduction. Inborn errors of immunity include a broad spectrum of genetic diseases, in which a specific gene mutation might alter the entire emphasis and approach for an individual patient. Objective.
Mónica Fernandes Pineda, Andrés F. Zea-Vera   +1 more
doaj   +1 more source

Comparison of RNA Extraction Methods for Molecular Analysis of Oral Cytology

Acta Stomatologica Croatica, 2016
Objective of work: The aim of this study was to compare three methods of RNA extraction for molecular analysis of oral cytology to establish the best technique, considering its concentration and purity for molecular tests of oral lesions such as real ...
Mônica Ghislaine Oliveira Alves, Mario Pérez-Sayáns, Maria-Elena Padín-Iruegas, Maria Dolores Reboiras-López, José Manuel Suarez-Peñaranda, Rafael López-López, Celina Faig Lima Carta, Jaqueline Scholz Issa, Abel García-García, Janete Dias Almeida   +9 more
doaj   +1 more source