Results 111 to 120 of about 11,582,729 (334)

Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model

EJNMMI Research
Background In non-insulin-dependent, type 2, diabetes mellitus (T2D), glucose metabolism is compromised, and the heart loses its metabolic flexibility.
Etienne Croteau, Gabriel Richard, Patrick Prud’Homme, Etienne Rousseau, Stephen C. Cunnane, Véronique Dumulon-Perreault, Otman Sarrhini, Serge Phoenix, Sébastien Tremblay, Brigitte Guérin, Roger Lecomte   +10 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Developing a Bright NIR‐II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD‐L1

Advanced Functional Materials, 2018
Fluorescence imaging in the second near‐infrared (NIR‐II) window holds impressive advantages of enhanced penetration depth and improved signal‐to‐noise ratio.
Hao Wan, Huilong Ma, Shoujun Zhu, Feifei Wang, Ye Tian, Rui Ma, Qinglai Yang, Zhubin Hu, T. Zhu, Weizhi Wang, Zhuoran Ma, Mingxi Zhang, Y. Zhong, Haitao Sun, Yongye Liang, H. Dai   +15 more
semanticscholar   +1 more source

Silicon Wafer Gettering Design for Advanced CMOS Image Sensors Using Hydrocarbon Molecular Ion Implantation: A Review [PDF]

, 2021
Kazunari Kurita, Takeshi Kadono, Ryosuke Okuyama, Ayumi Onaka‐Masada, Satoshi Shigematsu, Ryo Hirose, Kôji Kobayashi, Akihiro Suzuki, Hidehiko Okuda, Yoshihiro Koga   +9 more
openalex   +1 more source

Assessment of a one-week ketogenic diet on brain glycolytic metabolism and on the status epilepticus stage of a lithium–pilocarpine rat model

Scientific Reports
The ketogenic diet (KD) has been shown to be effective in refractory epilepsy after long-term administration. However, its interference with short-term brain metabolism and its involvement in the early process leading to epilepsy remain poorly understood.
Matthieu Doyen, Clémentine Lambert, Emilie Roeder, Henri Boutley, Bailiang Chen, Julien Pierson, Antoine Verger, Emmanuel Raffo, Gilles Karcher, Pierre-Yves Marie, Fatiha Maskali   +10 more
doaj   +1 more source

Experiences from Clinical Research and Routine Use of Florbetaben Amyloid PET—A Decade of Post-Authorization Insights

Pharmaceuticals
Florbetaben (FBB) is a radiopharmaceutical approved by the FDA and EMA in 2014 for the positron emission tomography (PET) imaging of brain amyloid deposition in patients with cognitive impairment who are being evaluated for Alzheimer’s disease (AD) or ...
Aleksandar Jovalekic, Santiago Bullich, Núria Roé-Vellvé, Guilherme Domingues Kolinger, Lorelei R. Howard, Floriana Elsholz, Mariana Lagos-Quintana, Beatriz Blanco-Rodriguez, Esther Pérez-Martínez, Rossella Gismondi, Audrey Perrotin, Marianne Chapleau, Richard Keegan, Andre Mueller, Andrew W. Stephens, Norman Koglin   +15 more
doaj   +1 more source

Bacteria-cancer interactions: bacteria-based cancer therapy

Experimental and Molecular Medicine, 2019
Cancer: tumor-targeting bacteria enter the anticancer arsenal Live tumor-targeting bacteria can selectively induce cancer regression and, with the help of genetic engineering, be made safe and effective vehicles for delivering drugs to tumor cells.
Mai Thi-Quynh Duong, Yeshan Qin, Sung-Hwan You, Jung-Joon Min   +3 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system. [PDF]

, 2019
LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technology has largely been confined to anatomic imaging with limited applications into functional or molecular imaging.
Hariri, Ali, Jeevarathinam, Ananthakrishna Soundaram, Jokerst, Jesse V, Lemaster, Jeanne, Zhang, Jianjian, Zhao, Eric   +5 more
core  

Immunotargeting of Integrin αβ for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model

Molecular Imaging, 2016
To explore suitable imaging probes for early and specific detection of pancreatic cancer, we demonstrated that α 6 β 4 integrin is a good target and employed single-photon emission computed tomography (SPECT) or near-infrared (NIR) imaging for ...
Winn Aung MBBS, PhD, Atsushi B. Tsuji PhD, Hitomi Sudo PhD, Aya Sugyo M.Ed, Takako Furukawa PhD, Yoshinori Ukai PhD, Yoshikazu Kurosawa PhD, Tsuneo Saga MD, PhD   +7 more
doaj   +1 more source