Results 281 to 290 of about 1,749,054 (354)

Vitamin A regulation of gene expression: molecular mechanism of a prototype gene

Journal of Nutritional Biochemistry, 2007
Vitamin A regulation of gene expression is a well-characterized example of direct nutrient regulation of gene expression. The downstream metabolites of retinol, all-trans and 9-cis retinoic acids are the bioactive components that bind and activate their cognate nuclear receptors to regulate target genes.
M. McGrane
exaly   +4 more sources

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Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

Antioxidants & Redox Signaling, 2005
Several years have passed since NF-E2-related factor 2 (Nrf2) was demonstrated to regulate the induction of genes encoding antioxidant proteins and phase 2 detoxifying enzymes. Following a number of studies, it was realized that Nrf2 is a key factor for cytoprotection in various aspects, such as anticarcinogenicity, neuroprotection, antiinflammatory ...
Makoto, Kobayashi, Masayuki, Yamamoto
openaire   +3 more sources

Transcriptome expression analysis of the gene regulation mechanism of bacterial mineralization tolerance to high concentrations of Cd2.

Science of the Total Environment, 2021
Cadmium (Cd) pollution is a pressing environmental issue that must be addressed. In recent years, microbial mineralization biotechnology has been developed into an effective and eco-friendly heavy metal bioremediation solution.
Shanshan Huang, Renlu Liu, Meng Sun, Xiaofang Li, Yong Guan, B. Lian   +5 more
semanticscholar   +1 more source

Regulation of gene expression by glycolytic and gluconeogenic enzymes.

Trends in Cell Biology, 2022
Gene transcription and cell metabolism are two fundamental biological processes that mutually regulate each other. Upregulated or altered expression of glucose metabolic genes in glycolysis and gluconeogenesis is a major driving force of enhanced aerobic
Xueli Bian, Hongfei Jiang, Ying Meng, Ying-ping Li, Jing Fang, Zhimin Lu   +5 more
semanticscholar   +1 more source

Regulation of cytochrome P450 genes: molecular mechanisms

Pharmacogenetics, 1993
The xenobiotic-metabolizing cytochrome P450s are found in the CYP1, CYP2, CYP3 and CYP4 subfamilies (Gonzalez, 1988). These P450s have been extensively studied in a number of organisms including bacteria, yeast, fish, chickens, rats, mice, rabbits and humans.
F J, Gonzalez, S Y, Liu, M, Yano
openaire   +2 more sources

Molecular mechanisms of cAMP-regulated gene expression

Molecular Neurobiology, 1990
The ability of many genes to be induced by cAMP is dependent on the presence of enhancers located in the regions of DNA upstream of the start sites to the genes. The two best characterized enhancers are the CRE (5'-TGACGTCA-3') and the AP-2 site (5'-CCCCAGGC-3').
K M, Walton, R P, Rehfuss
openaire   +2 more sources

Amino acids as regulators of gene expression: molecular mechanisms

Biochemical and Biophysical Research Communications, 2004
Regulation of gene expression by nutrients in mammals is an important mechanism allowing them to adapt their physiological functions according to the supply of nutrient in the diet. It has been shown recently that amino acids are able to regulate by themselves the expression of numerous genes.
Jousse, Céline, Averous, Julien, Bruhat, Alain, Carraro, Valérie, Mordier, Sylvie, Fafournoux, Pierre   +5 more
openaire   +3 more sources

Molecular mechanisms of gonadotropin-releasing hormone receptor gene regulation

Journal of the Society for Gynecologic Investigation, 1999
GnRH plays a critical role in regulating mammalian reproductive development and function. At the level of the anterior pituitary, GnRH binds to the GnRH receptor (GnRHR) on the cell surface of pituitary gonadotropes. Here, it activates intracellular signal transduction pathways to effect both the synthesis and intermittent release of the gonadotropins ...
E R, Norwitz, K H, Jeong, W W, Chin
openaire   +2 more sources

Molecular mechanisms of age-related regulation of genes

International Congress Series, 2004
Abstract Through transgenic mouse analyses of age-related expression of human genes, we recently discovered the first molecular mechanism of age-related regulation of gene expression, a critical finding for understanding the age-dimension homeostasis.
Kotoku Kurachi, Sumiko Kurachi, Kezhong Zhang, Afshin Ameri, Jeffrey Huo, Mitsuhiro Kuwahara, Jean-Marc Fontaine, Takahiro Abe   +7 more
openaire   +1 more source