Results 291 to 300 of about 1,749,054 (354)
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Methods for Assessing the Molecular Mechanisms Controlling Gene Regulation
2005Regulation of gene expression is a complex process that can be controlled at several steps,including transcription, pre-mRNA splicing and export, mRNA stability, translation, protein modification, and protein half-life. Because transcriptional regulation often involves DNA-protein interactions, several techniques are used, including nuclear run-off ...
Richard A, Rippe, Branko, Stefanovic
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Molecular Mechanisms of Gastrin‐Dependent Gene Regulation
Annals of the New York Academy of Sciences, 2004Abstract: The peptide hormone gastrin is the key regulator of gastric acid secretion. Gastrin exerts its effects as acid secretagogue through functional activation of gastric enterochromaffin‐like (ECL) cells, which control acid secretion through biosynthesis and release of histamine. In ECL cells, concerted activation of histidine decarboxylase (HDC),
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Molecular Mechanisms in Proenkephalin Gene Regulation
1993Proenkephalin (PENK) belongs to a family of three genes encoding peptides possessing opiate-like activity. Expression of the PENK gene is developmentally regulated in a tissue-specific manner. Widely expressed during embryogenesis in mitotic cells (Keshet et al. 1989), its expression is progressively restricted upon terminal differentiation.
N. Kley, J. P. Loeffler
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Molecular Regulation of CBF Signaling in Cold Acclimation.
Trends in Plant Science, 2018Cold stress restricts plant growth, development, and distribution. Understanding how plants transduce and respond to cold signals has long been a topic of interest. Traditional genetic and molecular analyses have identified C-repeat/DREB binding factors (
Yiting Shi, Yanglin Ding, Shuhua Yang
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Amino acids as regulators of gene expression in mammals: Molecular mechanisms
BioFactors, 2009AbstractIn mammals, the impact of nutrients on gene expression has become an important area of research. Because amino acids have multiple and important functions, their homeostasis has to be finely maintained. However, amino acidemia can be affected in some nutritional conditions and by various forms of stress.
Bruhat, Alain +5 more
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Molecular mechanisms regulating CD19, CD20 and CD22 gene expression
Immunology Today, 1994The CD19, CD20 and CD22 genes encode transmembrane proteins that are of vital importance to B-cell function. Similar to the immunoglobulin (Ig) genes, they are expressed in a lineage-specific and developmentally regulated manner. Here, John Kehrl and colleagues describe how an understanding of the transcriptional regulation of the CD19, CD20 and CD22 ...
J H, Kehrl +3 more
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Molecular Mechanisms of Regulation of Gene Expression by Glucocorticoids
1993The current model of glucocorticoid hormone action is summarized in Fig. 1. After synthesis, glucocorticoids are secreted into the blood stream and transported to target cells where they bind with high affinity (K d~10−9 M) and specificity to the intracellular glucocorticoid receptor (GR) protein.
Y. Dong, S. Okret, J.-Å. Gustafsson
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Molecular mechanisms of ethylene regulation of gene transcription
Physiologia Plantarum, 1997Ethylene‐regulated gene transcription has been studied in the context of plant defense, carnation flower petal senescence, and tomato fruit ripening. This review summarizes what is known about the molecular mechanisms of this process. Activation of plant defense genes in response to ethylene involves a promoter element called the GCC box, which ...
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Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes
Biochemical and Biophysical Research Communications, 2005AhR, a ligand-activated transcription factor, mediates xenobiotic signaling to enhance the expression of target genes, including drug-metabolizing cytochrome P450s. The recent development of several new techniques, including chromatin immunoprecipitation and RNA interference, has expanded and deepened our knowledge of AhR function in the xenobiotic ...
Y, Fujii-Kuriyama, J, Mimura
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Molecular Mechanisms Regulating Oxytocin Gene Expression
1993The hypothalamic nonapeptide oxytocin (OT) acts as a circulating hormone and as a neurotransmitter. Moreover, peripherally produced OT may function as a paracrine mediator. Despite the manifold sites of OT secretion and OT action, all its diverse effects are intimately related to the physiology of reproduction.
Hans H. Zingg +2 more
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