Results 161 to 170 of about 395,686 (301)

An Artificial Protein-Based Burnt-Bridges Molecular Motor Design [PDF]

Biophysical Journal, 2020
Chapin S. Korosec, Nancy R. Forde
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Brain-Derived Neurotrophic Factor Trafficking via the Regulated Secretory Pathway: Mechanisms and Disease Implications. [PDF]

Mol Neurobiol
Ewell SN.
europepmc   +1 more source

Molecular Genetic Study of Motor Protein KIF21B

Molecular Genetic Study of Motor Protein KIF21B
学位の種別: 課程博士 審査委員会委員 : （主査）東京大学教授 岡部 繁男, 東京大学教授 狩野 方伸, 東京大学教授 宮崎 徹, 東京大学講師 栗原 由紀子, 東京大学准教授 鯉沼 ...
openaire  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Calpain-2 Regulates Kinesin and Dynein Dysfunction in Neurotoxin-Induced Motoneuron Injury. [PDF]

Brain Sci
Zaman V, Green C, Sitgreaves K, Gathings A, Drasites KP, Coleman N, Huell J, McDonald T, Banik NL, Haque A.   +9 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

['IDENTIFYING MOLECULAR FUNCTIONS OF DYNEIN MOTOR PROTEINS USING EXTREME GRADIENT BOOSTING ALGORITHM WITH MACHINE LEARNING']

Journal of Mountain Area Research, 2022
Ali Ghulam, Rahu Sikander, Dhani Bux Talpur, Erum Saba, Mir Sajjad Hussain Talpur, Zulfikar Ahmed Maher, Saima Tunio   +6 more
doaj   +1 more source

4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy. [PDF]

Nat Commun
Martinez-Valbuena I, Lee S, Santamaria E, Fernández-Irigoyen J, Forrest SL, Zampar S, Li J, Tanaka H, Couto B, Gil D Reyes N, Qamar SH, Karakani AM, Kim A, Senkevich K, Rogaeva E, Fox SH, Tartaglia MC, Visanji NP, Ingelsson M, Andrews T, Lang AE, Kovacs GG.   +21 more
europepmc   +1 more source