Results 181 to 190 of about 392,762 (297)

Motor Protein Disruption Critically Alters Organelle Trafficking and Excitation-Contraction Coupling. [PDF]

eNeuro
Bansal H, Hana TA, Michael AH, Kamaridinova S, Bransford J, Ormerod KG.   +5 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

A first-principles quantitative framework for how cohesin regulators shape chromatin loop extrusion. [PDF]

Cell Genom
Huang Z, Liu X, Ding J.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Insight into the Interactions Between GhXI-K and Rab GTPases in Cotton Fiber. [PDF]

Plants (Basel)
Li X, Hao B, Li J, Jia Y.
europepmc   +1 more source

2P145 Mechanical principle of the motor protein KIF1A studied by molecular dynamics simulation(Molecular motors,Poster Presentations)

Seibutsu Butsuri, 2007
Takeshi Kuwata, Kei-ichi Okazaki, Rie Tatsumi, Nobuyasu Koga, Shoji Takada   +4 more
openaire   +2 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets. [PDF]

MedComm (2020)
Song DY, Yuan L, Yang W, Li W, Li JY.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Engram Synapses and Synapse Dynamics in Memory Processing. [PDF]

J Neurochem
Sung Y, Lee C, Jung H, Kaang BK.
europepmc   +1 more source