Results 201 to 210 of about 230,073 (294)

Nuclei on the move: LINC complex-dependent and -independent mechanisms of nuclear migration in development. [PDF]

Nucleus
Gümüşderelioğlu S, Gant Luxton GW, Starr DA.   +2 more
europepmc   +1 more source

Molecular Genetic Study of Motor Protein KIF21B

Molecular Genetic Study of Motor Protein KIF21B
学位の種別: 課程博士 審査委員会委員 : （主査）東京大学教授 岡部 繁男, 東京大学教授 狩野 方伸, 東京大学教授 宮崎 徹, 東京大学講師 栗原 由紀子, 東京大学准教授 鯉沼 ...
openaire  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Molecular neurobiological insights on integrative role of Trk neurotrophic receptors and their small-molecule agonists in neurodegenerative conditions. [PDF]

Exp Brain Res
Sanjai M, Jeyabalan JB, Alagesan VP, Saravanan SL, Clement JP, Justin A.   +5 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Misfolded Proteins and Cognitive Decline: Mechanistic Insights into Neurodegenerative Disorders. [PDF]

Neurol Int
Duranti E, Villa C.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

2P145 Mechanical principle of the motor protein KIF1A studied by molecular dynamics simulation(Molecular motors,Poster Presentations)

Seibutsu Butsuri, 2007
Takeshi Kuwata, Kei-ichi Okazaki, Rie Tatsumi, Nobuyasu Koga, Shoji Takada   +4 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Role of Sigmar1 in Autophagy Regulation and Disease Therapy. [PDF]

Int J Mol Sci
Ge H, Lin Y, Li J, Zhang R, Xu C.
europepmc   +1 more source