Results 201 to 210 of about 392,762 (297)

3P146 Simultaneous tracking of multiple motor proteins in nanoscale(11. Molecular motor,Poster)

Seibutsu Butsuri, 2013
Taishi Kakizuka, Keigo Ikezaki, Hideaki Fujita, Taro Ichimura, Tomonobu Watanabe   +4 more
openaire   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Synaptic changes contribute to persistent extra-motor behaviour deficits in amyotrophic lateral sclerosis. [PDF]

Acta Neuropathol Commun
Luan W, San Gil R, Madrid San Martin L, Cao MC, Vassallu F, Venturato J, West PK, Brown-Wright H, Bademosi AT, Chye YJ, Wu HY, Harutyunyan A, Robinson KJ, Chang MS, Blizzard CA, Scotter EL, Igaz LM, Walker AK.   +17 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Aer is a bidirectional redox sensor mediating negative chemotaxis to antibiotic-induced ROS in <i>Escherichia coli</i>. [PDF]

mBio
Bhattarai N, Moore JP, Payne S, Harshey RM.   +3 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch. [PDF]

Elife
Shukla S, Cross JA, Kish M, Yadav SKN, Weijman JF, O'Regan L, Mantell J, Borucu U, Leng X, Schaffitzel C, Phillips JJ, Woolfson DN, Dodding MP.   +12 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review. [PDF]

Int J Mol Sci
Kurdi MA, Alotaibi H, Alkhuraymi AT, Aldahery LN, Alhawaj AF, Aldali HJ.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source