Results 201 to 210 of about 395,686 (301)

Preliminary Evidence for Increased Histone Succinylation as a Potential Epigenetic Marker for Longevity. [PDF]

Aging Cell
Stransky S, Graff S, Mao K, Huffman DM, Milman S, Barzilai N, Sidoli S.   +6 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Emerging Roles of Tubulin Isoforms and Their Post-Translational Modifications in Microtubule-Based Transport and Cellular Functions. [PDF]

Biomolecules
Nair AR, Saroj N, Kunwar A.
europepmc   +1 more source

3P146 Simultaneous tracking of multiple motor proteins in nanoscale(11. Molecular motor,Poster)

Seibutsu Butsuri, 2013
Taishi Kakizuka, Keigo Ikezaki, Hideaki Fujita, Taro Ichimura, Tomonobu Watanabe   +4 more
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Nuclear myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors. [PDF]

J Biol Chem
Jayawardana IM, Fleisch JM, Knerr J, Wang H, Holst M, Tholen S, Schilling O, Grosse R.   +7 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Proceedings of the 12^th International Meeting on Neuroacanthocytosis, Cohen Syndrome, and Other VPS13-Related Disorders. [PDF]

Tremor Other Hyperkinet Mov (N Y)
Vacca F, Yalcin B, Kaestner L, Danek A, Peikert K, Walker RH, Ansar M.   +6 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Pathological and Molecular Insights into the Early Stage of Multiple System Atrophy. [PDF]

Cells
Tanaka MT, Miki Y, Kon T, Mori F, Wakabayashi K.   +4 more
europepmc   +1 more source