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Protein‐protein interactions play significant roles in molecular motors
The FASEB Journal, 2022Dynein is a molecular motor for cargo transportation and force generation in cells. Dysfunction of dynein is associated with many diseases, such as ciliopathies, lissencephaly and other neurodegeneration disorders. Understanding the functions of dynein is crucial for developing new treatments of such diseases.
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Chromosome distribution, molecular motors and the claret protein
Trends in Genetics, 1993Recently, proteins have been identified that are required for proper distribution of chromosomes in meiosis and mitosis. Unexpectedly, several of these are microtubule motor proteins. This finding has prompted further investigation into the basis of meiotic and mitotic chromosome movement.
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Models of protein linear molecular motors for dynamic nanodevices
Integr. Biol., 2009Protein molecular motors are natural nano-machines that convert the chemical energy from the hydrolysis of adenosine triphosphate into mechanical work. These efficient machines are central to many biological processes, including cellular motion, muscle contraction and cell division.
Fulga, Florin +2 more
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AFM protein–protein interactions within the EcoR124I molecular motor
Soft Matter, 2012Dynamic Force Spectroscopy (DFS), an Atomic Force Microscopy (AFM) technique, has been used to investigate the interaction between the HsdR subunit and the core methylase (MTase) of the Type I Restriction-Modification (R-M) enzyme EcoR124I. Such systems are of interest in bionanotechnology owing to their ability to translocate DNA, thus acting as ...
Sikora, A. +3 more
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Protein in action: molecular motors
2005Molecular motors: energy from ATP Proteins can be grouped into a few broad categories with respect to their function. Some are regulatory, some are enzymes, some are structural, and some proteins do mechanical work. It is this latter group that we now discuss.
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Motor protein motion along microtubules for molecular detection
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, 2011A molecular detection system was realized using the change in the characteristics of the kinesin-coated bead motion along protein-attached microtubules. A hybrid bio/microfluidics device with a microtubule immobilized main channel and protein-injected sub-channels allowed us to compare different protein attachments and several control experiments with ...
M.C. Tarhan +4 more
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Molecular phylogeny of the kinesin family of microtubule motor proteins
Journal of Cell Science, 1994ABSTRACT The rapidly expanding kinesin family of microtubule motor proteins includes proteins that are involved in diverse microtubule-based functions in the cell. Phylogenetic analysis of the motor regions of the kinesin proteins reveals at least five clearly defined groups that are likely to identify kinesins with different roles in ...
H V, Goodson, S J, Kang, S A, Endow
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Biochemical and molecular characterization of diseases linked to motor proteins
Trends in Biochemical Sciences, 2003Recent studies have revealed that kinesin, dynein and myosin each form large superfamilies and participate in many different intracellular transport systems. Importantly, these motor proteins play significant roles in the pathogenesis of a variety of diseases.
Nobutaka, Hirokawa, Reiko, Takemura
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Self-organization versus Watchmaker: Molecular motors and protein translocation
Biosystems, 2006Generation of directional movement at the molecular scale is a phenomenon crucial for biological organization and dynamics. It is traditionally described in mechanistic terms, in consistency with the conventional machine-like image of the cell. The designated and highly specialized protein machines and molecular motors are presumed to bring about most ...
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Mechanical Characterization of Motor Proteins: A Molecular Dynamics Approach
Macromolecular Theory and Simulations, 2008AbstractA new approach, based on molecular dynamics, is presented to measure the mechanical properties of motor proteins, which are important for accomplishing their intracellular functions. Two different set‐ups were designed to mimic the optical tweezers and surface force apparatus experiments. The results obtained show that the stiffness and elastic
Iuliana Aprodu +2 more
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