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Molecular switch-like regulation in motor proteins [PDF]
Motor proteins are powered by nucleotide hydrolysis and exert mechanical work to carry out many fundamental biological tasks. To ensure their correct and efficient performance, the motors' activities are allosterically regulated by additional factors ...
Carlos Bustamante, Sara Tafoya
exaly +7 more sources
Motor proteins and molecular motors: how to operate machines at the nanoscale [PDF]
Several classes of biological molecules that transform chemical energy into mechanical work are known as motor proteins or molecular motors. These nanometer-sized machines operate in noisy stochastic isothermal environment, strongly supporting ...
Anatoly B Kolomeisky
exaly +6 more sources
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Molecular movie of nucleotide binding to a motor protein
Biochimica et Biophysica Acta (BBA) - General Subjects, 2020The SecA DEAD (Asp-Glu-Ala-Asp) motor protein uses binding and hydrolysis of adenosine triphosphate (ATP) to push secretory proteins across the plasma membrane of bacteria. The reaction coordinate of nucleotide exchange is unclear at the atomic level of detail.We performed multiple atomistic computations of the DEAD motor domain of SecA with different ...
Ana-Nicoleta, Bondar +2 more
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Engineered Pendrin Protein, an Anion Transporter and Molecular Motor* [PDF]
Pendrin and prestin both belong to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Pendrin (SLC26A4) is a chloride-iodide transporter that is found at the luminal membrane of follicular cells in the thyroid gland as well as in the endolymphatic duct and sac of the inner ear, whereas prestin (SLC26A5) is expressed in ...
David Z Z He, Xiaodong Tan
exaly +3 more sources
Conformational dynamics of ATP/Mg:ATP in motor proteins via data mining and molecular simulation
The conformational diversity of ATP/Mg:ATP in motor proteins was investigated using molecular dynamics and data mining. Adenosine triphosphate (ATP) conformations were found to be constrained mostly by inter cavity motifs in the motor proteins.
Richard J. Sadus, Ming S Liu
exaly +2 more sources
Molecular Assembly of Rotary and Linear Motor Proteins
Accounts of Chemical Research, 2019Molecular machines are an important and emerging frontier in research encompassing interdisciplinary subjects of chemistry, physics, biology, and nanotechnology. Although there has been major interest in creating synthetic molecular machines, research on natural molecular machines is also crucial.
Yi Jia, Junbai Li
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Regulation of molecular motor proteins
2001Motor proteins in the kinesin, dynein, and myosin superfamilies are tightly regulated to perform multiple functions in the cell requiring force generation. Although motor proteins within families are diverse in sequence and structure, there are general mechanisms by which they are regulated.
A R, Reilein +3 more
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