Results 271 to 280 of about 5,860,920 (296)
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Building artificial networks of protein molecular motors
SPIE Proceedings, 1997This study attempts to assess the feasibility of building purposefully designed molecular motor arrays, the proteins responsible for the movements of the living organisms and cells. The 'building' process used high-resolution e-beam patterning, originating in semiconductor technology, upgraded to make biomicrolithography compatible with the patterning ...
Dan V. Nicolau +5 more
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Protein‐protein interactions play significant roles in molecular motors
The FASEB Journal, 2022Dynein is a molecular motor for cargo transportation and force generation in cells. Dysfunction of dynein is associated with many diseases, such as ciliopathies, lissencephaly and other neurodegeneration disorders. Understanding the functions of dynein is crucial for developing new treatments of such diseases.
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AFM protein–protein interactions within the EcoR124I molecular motor
Soft Matter, 2012Dynamic Force Spectroscopy (DFS), an Atomic Force Microscopy (AFM) technique, has been used to investigate the interaction between the HsdR subunit and the core methylase (MTase) of the Type I Restriction-Modification (R-M) enzyme EcoR124I. Such systems are of interest in bionanotechnology owing to their ability to translocate DNA, thus acting as ...
Sikora, A. +3 more
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The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET
Journal of Molecular Biology, 2015HAMLET (human alpha-lactalbumin made lethal to tumor cells) interacts with multiple tumor cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin structure and viability. This study investigated if these diverse effects of HAMLET might be caused, in part, by a direct effect on the ATP synthase and a resulting reduction ...
James Ho +4 more
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Mechanical Characterization of Motor Proteins: A Molecular Dynamics Approach
Macromolecular Theory and Simulations, 2008AbstractA new approach, based on molecular dynamics, is presented to measure the mechanical properties of motor proteins, which are important for accomplishing their intracellular functions. Two different set‐ups were designed to mimic the optical tweezers and surface force apparatus experiments. The results obtained show that the stiffness and elastic
Iuliana Aprodu +2 more
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Motor protein motion along microtubules for molecular detection
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, 2011A molecular detection system was realized using the change in the characteristics of the kinesin-coated bead motion along protein-attached microtubules. A hybrid bio/microfluidics device with a microtubule immobilized main channel and protein-injected sub-channels allowed us to compare different protein attachments and several control experiments with ...
M.C. Tarhan +4 more
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Dynamic Nanodevices Based on Protein Molecular Motors
2007Most of the present micro/nano biodevices are designed for a single use, as opposed to ‘classical’ non-biodevices (e.g., from the steam engine to the microchip). Once their function, be that simple molecular recognition like in microarrays or even biomolecular computation as in DNA computation arrays, is fulfilled and the information is passed further ...
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Switches, latches, and amplifiers: common themes of G proteins and molecular motors.
Journal of Cell Biology, 1996Ronald Vale
exaly