Results 41 to 50 of about 5,894,644 (362)
Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes.
Journal of the American Chemical Society, 2017 Exosomes are membrane-enclosed extracellular vesicles derived from cells, carrying biomolecules that include proteins and nucleic acids for intercellular communication.
Shuo Wan +11 more
semanticscholar +1 more source
Essays in Biochemistry, 2017 Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought ‘undruggable’ targets at sub-stoichiometric concentrations in
S. Hughes, A. Ciulli
semanticscholar +1 more source
Entropy in molecular recognition by proteins
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Molecular recognition by proteins is a key element of biology. Appreciation of the underlying thermodynamics has been incomplete because of uncertainty in several contributions to the entropy. Here, we demonstrate a way to measure changes in
José A. Caro +7 more
semanticscholar +1 more source
Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source
Peptide Linker Affecting the Activity Retention Rate of VHH in Immunosorbents
Biomolecules, 2020 VHH-based immunosorbents are an emerging and promising tool for the removal of toxic substances from plasma. However, the small size of VHHs is a double-edged sword, bringing both benefits and drawbacks to the immunosorbent.
Da Li +5 more
doaj +1 more source
Chemical Society Reviews, 2017 Chemotherapy is currently one of the most effective ways to treat cancer. However, traditional chemotherapy faces several obstacles to clinical trials, such as poor solubility/stability, non-targeting capability and uncontrollable release of the drugs ...
Jiong Zhou, Guocan Yu, Feihe Huang
semanticscholar +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Sensors, 2022 Reinforced concrete structures’ (RCSs) ageing and early deterioration are some of the main challenges faced by the building sector today, and steel bar corrosion is one of the main problems.
Ana Martínez Ibernón +3 more
doaj +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Molecules, 2019 Capillary electrophoresis using laser-induced fluorescence detection (CE-LIF) is one of the most sensitive separation tools among electrical separation methods.
Binh Thanh Nguyen, Min-Jung Kang
doaj +1 more source