Results 51 to 60 of about 6,845,981 (383)

High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1. [PDF]

, 2018
Polybromo-1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl-lysine residues.
Alicea-Velázquez, Nilda L., Cai, Weijia, Cho, Eun-Ah, Cosgrove, Michael S., Greer, Celeste B., Langbein, Lauren, Liao, Lili, Niu, Xiaohua, Yan, Qin, Yang, Haifeng, Zhang, Meiling   +10 more
core   +2 more sources

Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

Essays in Biochemistry, 2017
Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought ‘undruggable’ targets at sub-stoichiometric concentrations in
S. Hughes, A. Ciulli
semanticscholar   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Optoelectronic sensitization of carbon nanotubes by CdTe nanocrystals [PDF]

, 2009
We investigate the photoconductance of single-walled carbon nanotube-nanocrystal hybrids. The nanocrystals are bound to the nanotubes via molecular recognition.
Carmeli, I., Hartschuh, Achim, Holleitner, Alexander W., Kotthaus, Jörg P., Vieyra, H. A., Zebli, B.   +5 more
core   +2 more sources

Radically enhanced molecular recognition

Nature Chemistry, 2009
The tendency for viologen radical cations to dimerize has been harnessed to establish a recognition motif based on their ability to form extremely strong inclusion complexes with cyclobis(paraquat-p-phenylene) in its diradical dicationic redox state.
Trabolsi, Ali, Khashab, Niveen, Fahrenbach, Albert C., Friedman, Douglas C., Colvin, Michael T., Cotí, Karla K., Benítez, Diego, Tkatchouk, Ekaterina, Olsen, John-Carl, Belowich, Matthew E., Carmielli, Raanan, Khatib, Hussam A., Goddard, William A., III, Wasielewski, Michael R., Stoddart, J. Fraser   +14 more
openaire   +3 more sources

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Peptide Linker Affecting the Activity Retention Rate of VHH in Immunosorbents

Biomolecules, 2020
VHH-based immunosorbents are an emerging and promising tool for the removal of toxic substances from plasma. However, the small size of VHHs is a double-edged sword, bringing both benefits and drawbacks to the immunosorbent.
Da Li, Jun Ren, Fangling Ji, Qiang Peng, Hu Teng, Lingyun Jia   +5 more
doaj   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Application of Capillary Electrophoresis with Laser-Induced Fluorescence to Immunoassays and Enzyme Assays

Molecules, 2019
Capillary electrophoresis using laser-induced fluorescence detection (CE-LIF) is one of the most sensitive separation tools among electrical separation methods.
Binh Thanh Nguyen, Min-Jung Kang
doaj   +1 more source

Estimation of Humidity Variation and Electric Resistivity in Hardened Concrete by Means of a Stainless Steel Voltammetric Sensor

Sensors, 2022
Reinforced concrete structures’ (RCSs) ageing and early deterioration are some of the main challenges faced by the building sector today, and steel bar corrosion is one of the main problems.
Ana Martínez Ibernón, Josep Lliso Ferrando, Isabel Gasch, Manuel Valcuende   +3 more
doaj   +1 more source