Results 61 to 70 of about 4,241,168 (373)

Bootstrap confidence for molecular evolutionary estimates from tumor bulk sequencing data

Frontiers in Bioinformatics, 2023
Bulk sequencing is commonly used to characterize the genetic diversity of cancer cell populations in tumors and the evolutionary relationships of cancer clones. However, bulk sequencing produces aggregate information on nucleotide variants and their sample frequencies, necessitating computational methods to predict distinct clone sequences and their ...
Jared Huzar, Madelyn Shenoy, Maxwell D. Sanderford, Sudhir Kumar, Sudhir Kumar, Sudhir Kumar, Sayaka Miura, Sayaka Miura   +7 more
openaire   +3 more sources

Learning the molecular grammar of protein condensates from sequence determinants and embeddings

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The tendency of many cellular proteins to form protein-rich biomolecular condensates underlies the formation of subcellular compartments and has been linked to various physiological functions.
K. Saar, A. Morgunov, Runzhang Qi, William E. Arter, G. Krainer, A. Lee, T. Knowles   +6 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Nothing to hide: An X-ray survey for young stellar objects in the Pipe Nebula

, 2010
We have previously analyzed sensitive mid-infrared observations to establish that the Pipe Nebula has a very low star-formation efficiency. That study focused on YSOs with excess infrared emission (i.e, protostars and pre-main sequence stars with disks),
Agüeros, Bettina Posselt, Brooke, Charles J. Lada, Cieza, Covey, Feigelson, Forbrich, Jan Forbrich, Kenyon, Kevin R. Covey, Lada, Lasker, Muench, Mukai, Neuhäuser, Padgett, Preibisch, Rathborne, Robitaille, Voges, Voges   +21 more
core   +1 more source

Resurrection of the genus Staphisagria J. Hill, sister to all the other Delphinieae (Ranunculaceae) [PDF]

, 2011
Molecular sequence data show that the three species of Delphinium subg. Staphisagria (J. Hill) Peterm. form the sister clade to Aconitum L., Aconitella Spach, Consolida (DC.) S.F. Gray, and all remaining species of Delphinium L.
Jabbour, Florian, Renner, Susanne S.
core   +3 more sources

Reliability and Utility of Standard Gene Sequence Barcodes for the Identification and Differentiation of Cyst Nematodes of the Genus Heterodera

Journal of Nematology, 2022
Difficulties inherent in the morphological identification of cyst nematodes of the genus Heterodera Schmidt, 1871, an important lineage of plant parasites, has led to broad adoption of molecular methods for diagnosing and differentiating species.
Huston Daniel C., Khudhir Manda, Hodda Mike   +2 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Natural variability of Kozak sequences correlates with function in a zebrafish model. [PDF]

PLoS ONE, 2014
In eukaryotes, targeting the small ribosomal subunit to the mRNA transcript requires a Kozak sequence at the translation initiation site. Despite the critical importance of the Kozak sequence to regulation of gene expression, there have been no ...
Steven J Grzegorski, Estelle F Chiari, Amy Robbins, Phillip E Kish, Alon Kahana   +4 more
doaj   +1 more source

Phylogenetic diversity of insecticolous fusaria inferred from multilocus DNA sequence data and their molecular identification via FUSARIUM-ID and Fusarium MLST

Mycologia, 2012
We constructed several multilocus DNA sequence datasets to assess the phylogenetic diversity of insecticolous fusaria, especially focusing on those housed at the Agricultural Research Service Collection of Entomopathogenic Fungi (ARSEF), and to aid ...
K. O’Donnell, R. Humber, D. Geiser, Seogchan Kang, Bongsoo Park, V. Robert, P. Crous, P. Johnston, T. Aoki, A. Rooney, S. Rehner   +10 more
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source