Results 11 to 20 of about 2,123,606 (402)
Targeted Molecular Therapy in Glioblastoma [PDF]
Journal of Oncology, 2020 This special issue was aimed at updating researchers on current topics and progress made in basic, preclinical, and clinical glioblastoma research. It also provided a platform for pharmaceutical and translational scientists to submit original research ...
Festuccia, Claudio +4 more
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Frontiers in Bioscience-Landmark, 2023 Background: Pyroptosis plays a crucial role in anti-tumor immunity and in formation of the immune microenvironment. However, whether pyroptosis is involved in the progression of clear cell renal cell carcinoma (ccRCC) is still unclear.
Jinpeng Ma +12 more
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Clinical Cancer Research, 2022 PURPOSE Molecular targeted therapy using BRAF and/or MEK inhibitors has been applied to BRAFV600E mutant high-grade gliomas (HGGs); however, the therapeutic effect is limited by the emergence of drug resistance.
Jo Sasame +28 more
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Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis
Cell Death Discovery, 2021 The Hippo/YAP pathway plays an important role in the development of cancers. Previous studies have reported that bile acids can activate YAP (Yes Associated Protein) to promote tumorigenesis and tumor progression.
Huan Zhang +4 more
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Molecular Targets for AIDS Therapy [PDF]
Science, 1990 The development of antiretroviral therapy against acquired immunodeficiency syndrome (AIDS) has been an intense research effort since the discovery of the causative agent, human immunodeficiency virus (HIV). A large array of drugs and biologic substances can inhibit HIV replication in vitro.
Mitsuya, H., Yarchoan, R., Broder, S.
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Cell Death Discovery, 2021 Lipid homeostasis plays a fundamental role in the development of hepatocellular carcinoma (HCC). However, the mechanisms that regulate lipid homeostasis to avoid lipotoxicity in HCC remain elusive.
Meiling Ren +4 more
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Targeted Molecular Therapies for SBMA [PDF]
Journal of Molecular Neuroscience, 2015 Spinal and bulbar muscular atrophy (SBMA) is a late-onset neuromuscular disease caused by a polyglutamine expansion in the androgen receptor gene which results in progressive spinal and bulbar motor neuron degeneration, and muscle atrophy. Although the causative genetic defect is known, until recently, the molecular pathogenesis of the disease was ...
Rinaldi, C, Malik, B, Greensmith, L
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Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer
Cell Death Discovery, 2021 Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management.
Huanji Xu +4 more
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Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment
Journal of Experimental & Clinical Cancer Research, 2021 Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer.
Di Ye +5 more
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Review Hepatotoxicity of molecular targeted therapy [PDF]
Współczesna Onkologia, 2015 A constant increase in occurrence of neoplasms is observed; hence new methods of therapy are being intensively researched. One of the methods of antineoplastic treatment is molecular targeted therapy, which aims to influence individual processes occurring in cells.
Bożenna Karczmarek-Borowska +1 more
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