Results 21 to 30 of about 957,553 (357)

In Vivo Fluorescence Imaging of E-Selectin: Quantitative Detection of Endothelial Activation in Arthritis [PDF]

, 2010
Rheumatoid arthritis (RA) is a chronic progressive systemic inflammatory disease, characterized by synovial inflammation and localized destruction of cartilage and bone.
Gompels, Luke, Gompels, Luke
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Molecular targeted therapy of glioblastoma [PDF]

Cancer Treatment Reviews, 2019
Glioblastomas are intrinsic brain tumors thought to originate from neuroglial stem or progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH)-wildtype tumors. Incidence increases with age, males are more often affected. Beyond rare instances of genetic predisposition and irradiation exposure, there are no known glioblastoma ...
Le Rhun, Emilie, Preusser, Matthias, Roth, Patrick, Reardon, David, van den Bent, Martin, Wen, Patrick, Reifenberger, Guido, Weller, Michael   +7 more
openaire   +3 more sources

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited [PDF]

, 2012
The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2)
Dumont, Daniel J., Plate, Karl H., Scholz, Alexander   +2 more
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A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance

Frontiers in Cell and Developmental Biology, 2020
In recent years, as our understanding of tumor immunology is continuously improved, immunotherapy has come to the center stage of cancer therapy and is deemed as the most promising approach for cancer control.
Qian Huang, Yanna Lei, Xiaoying Li, Fukun Guo, Ming Liu   +4 more
doaj   +1 more source

A simplified genomic profiling approach predicts outcome in metastatic colorectal cancer [PDF]

, 2019
The response of metastatic colorectal cancer (mCRC) to the first-line conventional combination therapy is highly variable, reflecting the elevated heterogeneity of the disease.
Belardinilli, Francesca, Bellavia, Diana, Bonfiglio, Caterina, Canettieri, Gianluca, Capalbo, Carlo, Cardinali, Beatrice, Colella, Mariarosaria, Colicchia, Valeria, Coppa, Anna, Cortesi, Enrico, Filetti, Marco, Giannini, Giuseppe, Infante, Paola, Longo, Flavia, Magri, Valentina, Malapelle, Umberto, Marchetti, Paolo, Mezi, Silvia, Milanetti, Edoardo, Nicolussi, Arianna, Paci, Paola, Pecorari, Silvia, Petroni, Marialaura, Pisapia, Pasquale, Prete, Alessandra, Raimondo, Domenico, Santoni, Matteo, Tessitore, Alessandra, Troncone, Giancarlo, Valentini, Virginia   +29 more
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Clinical actionability of comprehensive genomic profiling for management of rare or refractory cancers [PDF]

, 2016
Background. The frequency with which targeted tumor sequencing results will lead to implemented change in care is unclear. Prospective assessment of the feasibility and limitations of using genomic sequencing is critically important. Methods.
Aisner, Joseph, Ali, Siraj M., Belyi, Vladimir, Bertino, Joseph R., Chan, Chang S., Chen, Suzie, DiPaola, Robert S., Foran, David, Ganesan, Shridar, Glod, John, Goodell, Lauri, Hirshfield, Kim M., Kaufman, Howard, Mehnert, Janice, Miller, Vincent A., Moss, Rebecca A., Murphy, Susan, Palma, Norma A., Poplin, Elizabeth, Rodriguez-Rodriguez, Lorna, Ross, Jeffrey S., Stein, Mark N., Stephens, Philip J., Sun, James X., Tan, Antoinette R., Tolkunov, Denis, Vazquez, Alexei, Vig, Hetal, Yelensky, Roman, Zhong, Hua   +29 more
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Menin–MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers

Molecules, 2023
Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition of the high-
Qing Shi, Meiqi Xu, Zhijian Kang, Manjie Zhang, Yakun Luo   +4 more
doaj   +1 more source

Management of imatinib-resistant CML patients [PDF]

, 2007
Imatinib has had marked impact on outcomes in chronic myelogenous leukemia (CML) patients for all stages of the disease and is endorsed by international treatment guidelines as the first line option.
Branford S, Burger H, Burgess MR, Cortes J, Crossman LC, Donato NJ, Druker BJ, Gambacorti-Passerini C, Giles F, Hochhaus A, Hughes TP, Iacobucci I, Kantarjian H, Lahaye T, Mahon FX, Melo JV, O'Hare T, Quintas-Cardama A, Rousselot P, Sleijfer S, Soverini S, Weisberg E   +21 more
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Major roles of the circadian clock in cancer

Cancer Biology & Medicine, 2023
Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the processes and physiological functions of various biochemical reactions. The circadian clock is critical for cancer occurrence and progression.
Chen Huang, Chenliang Zhang, Yubin Cao, Jian Li, Feng Bi   +4 more
doaj   +1 more source

Perillaldehyde improves cognitive function in vivo and in vitro by inhibiting neuronal damage via blocking TRPM2/NMDAR pathway

Chinese Medicine, 2021
Background Vascular cognitive dysfunction in patients with vascular dementia (VD) is a kind of severe cognitive dysfunction syndrome caused by cerebrovascular diseases.
Yue Qiu, Xian-jun Xue, Geng Liu, Miao-miao Shen, Chun-yan Chao, Jie Zhang, Ya-qi Guo, Qian-qian Niu, Ya-nan Yu, Yu-ting Song, Huan-huan Wang, Shuang-xi Wang, Yu-jing Chen, Lin-hua Jiang, Peng Li, Ya-ling Yin   +15 more
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