Results 31 to 40 of about 2,123,606 (402)

Molecular pathogenesis and targeted therapy of sporadic pancreatic neuroendocrine tumors [PDF]

, 2015
Over the past few years, knowledge regarding the molecular pathology of sporadic pancreatic neuroendocrine tumors (PNETs) has increased substantially, and a number of targeted agents have been tested in clinical trials in this tumor type.
Ahn, Balogh, Bergers, Berruti, Capurso, Capurso, Carew, Castellano, Chamberlain, Chan, Chan, Chen, Clynes, Corbo, Corbo, Couvelard, De Wilde, Di Florio, Di Florio, Di Florio, Fazio, Fendrich, Gaur, Gurung, Han, Heaphy, Heaphy, Hobday, Hopfner, House, Jacinto, Jensen, Jiao, Karnik, Karnik, Komori, Kulke, Laplante, Loewith, Lovejoy, Luzi, Marinoni, Marion-Audibert, Mendel, Meric-Bernstam, Missiaglia, Mocellin, Panzuto, Papouchado, Passacantilli, Perren, Pàez-Ribes, Raymond, Sarbassov, Scoazec, Shah, Shi, Tang, Vinagre, Wang, Yang, Yao, Yuan, Zhang, Zhang   +64 more
core   +1 more source

A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance

Frontiers in Cell and Developmental Biology, 2020
In recent years, as our understanding of tumor immunology is continuously improved, immunotherapy has come to the center stage of cancer therapy and is deemed as the most promising approach for cancer control.
Qian Huang, Yanna Lei, Xiaoying Li, Fukun Guo, Ming Liu   +4 more
doaj   +1 more source

Menin–MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers

Molecules, 2023
Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition of the high-
Qing Shi, Meiqi Xu, Zhijian Kang, Manjie Zhang, Yakun Luo   +4 more
doaj   +1 more source

Anlotinib as a molecular targeted therapy for tumors.

Oncology Letters, 2020
Angiogenesis has an essential role in tumor growth and metastasis, and blocking this pathway has been a successfully utilized strategy in the clinical treatment of cancer.
Yi Gao, Pengfei Liu, Ruihua Shi
semanticscholar   +1 more source

Molecular targets for therapy in systemic sclerosis [PDF]

Fibrogenesis & Tissue Repair, 2012
Despite significant advances have been made in the recent years regarding organ-specific therapies, there is no approved 'disease-modifying' antifibrotic drug for systemic sclerosis (SSc) available to date. Although non-selective immunosuppressive agents are routinely used to treat patients with SSc, large well-controlled studies are lacking for almost
Iwamoto, Naoki, Distler, Oliver
openaire   +3 more sources

Patient-centric trials for therapeutic development in precision oncology [PDF]

, 2015
An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours.
A Hollebecque, A-M Tsimberidou, AD Barker, AL Tam, Andrew V. Biankin, AT Shaw, AV Biankin, B Zhang, C Le Tourneau, C Le Tourneau, C Lin, C Printz, CK Lee, CR Lindsay, D Cook, D Slamon, D Zardavas, DD Von Hoff, DE Gerber, DJ Sargent, DT Le, EA Eisenhauer, ED Green, ES Kim, F André, GD Demetri, GM Frampton, IR Watson, J Ledermann, J Lewin, J Verweij, JA Sosman, JY Douillard, L Chin, L Chin, L Seguin, LA Chantrill, LB Alexandrov, LJ Esserman, LJ Esserman, M Hay, M Maemondo, MG Kris, MR Stratton, MR Stratton, N Roper, N Waddell, NM Hylton, PA Jänne, PN Lara Jr, R Dienstmann, R Simon, RR Kalf, S Matsumoto, S Sleijfer, Simon J. Hollingsworth, SJ Dawson, SJ Mandrekar, Steven Piantadosi, TA Yap, TJ Hudson   +60 more
core   +1 more source

Clinical actionability of comprehensive genomic profiling for management of rare or refractory cancers [PDF]

, 2016
Background. The frequency with which targeted tumor sequencing results will lead to implemented change in care is unclear. Prospective assessment of the feasibility and limitations of using genomic sequencing is critically important. Methods.
Aisner, Joseph, Ali, Siraj M., Belyi, Vladimir, Bertino, Joseph R., Chan, Chang S., Chen, Suzie, DiPaola, Robert S., Foran, David, Ganesan, Shridar, Glod, John, Goodell, Lauri, Hirshfield, Kim M., Kaufman, Howard, Mehnert, Janice, Miller, Vincent A., Moss, Rebecca A., Murphy, Susan, Palma, Norma A., Poplin, Elizabeth, Rodriguez-Rodriguez, Lorna, Ross, Jeffrey S., Stein, Mark N., Stephens, Philip J., Sun, James X., Tan, Antoinette R., Tolkunov, Denis, Vazquez, Alexei, Vig, Hetal, Yelensky, Roman, Zhong, Hua   +29 more
core   +1 more source

Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges [PDF]

, 2021
Research on molecular targeted therapy of tumors is booming, and novel targeted therapy drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy drugs, can be administered orally as tablets among other methods, and do not ...
Cao, Hongyong, Cheng, Ye, Li, Xiao, Li, Zhouxiao, Rong, Dawei, Sun, Guangshun, Sun, Guoqiang, Sun, Yangbai, Tang, Weiwei, Wu, Fan   +9 more
core   +2 more sources

Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials. [PDF]

, 2014
BackgroundKRAS mutation is common in human cancer. We assessed the clinical factors, including type of KRAS mutation and treatment, of patients with advanced cancer and tumor KRAS mutations and their association with treatment outcomes.MethodsPatients ...
Aldape, Kenneth, Blumenschein, George R, Falchook, Gerald Steven, Fu, Siqing, Hess, Kenneth R, Hong, David S, Janku, Filip, Kurzrock, Razelle, Naing, Aung, Palmer, Gary A, Piha-Paul, Sarina Anne, Said, Rabih, Tsimberidou, Apostolia Maria, Wheler, Jennifer J, Ye, Yang, Zinner, Ralph   +15 more
core   +11 more sources

Perillaldehyde improves cognitive function in vivo and in vitro by inhibiting neuronal damage via blocking TRPM2/NMDAR pathway

Chinese Medicine, 2021
Background Vascular cognitive dysfunction in patients with vascular dementia (VD) is a kind of severe cognitive dysfunction syndrome caused by cerebrovascular diseases.
Yue Qiu, Xian-jun Xue, Geng Liu, Miao-miao Shen, Chun-yan Chao, Jie Zhang, Ya-qi Guo, Qian-qian Niu, Ya-nan Yu, Yu-ting Song, Huan-huan Wang, Shuang-xi Wang, Yu-jing Chen, Lin-hua Jiang, Peng Li, Ya-ling Yin   +15 more
doaj   +1 more source