Results 41 to 50 of about 2,123,606 (402)

Targeting Oncogenic BRAF: Past, Present, and Future. [PDF]

, 2019
Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF has enabled a "precision medicine" paradigm to diagnose and treat BRAF-driven tumors.
Bivona, Trever G, Wu, Wei, Zaman, Aubhishek   +2 more
core   +1 more source

Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy

Frontiers in Oncology, 2023
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ...
Teng Tu, Hongying Zhang, Huanji Xu
doaj   +1 more source

T-cell infiltration in the central nervous system and their association with brain calcification in Slc20a2-deficient mice

Frontiers in Molecular Neuroscience, 2023
Primary familial brain calcification (PFBC) is a rare neurodegenerative and neuropsychiatric disorder characterized by bilateral symmetric intracranial calcification along the microvessels or inside neuronal cells in the basal ganglia, thalamus, and ...
Yi Zhang, Yi Zhang, Yaqiong Ren, Yueni Zhang, Yueni Zhang, Ying Li, Ying Li, Chao Xu, Chao Xu, Ziyue Peng, Ziyue Peng, Ying Jia, Ying Jia, Shupei Qiao, Shupei Qiao, Zitong Zhang, Zitong Zhang, Lei Shi, Lei Shi   +18 more
doaj   +1 more source

Glioma targeted therapy: insight into future of molecular approaches

Molecular Cancer, 2022
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically, gliomas occur among all ages, more often seen in adults, which males are more susceptible than females.
Keyang Yang, Zhijing Wu, Hao Zhang, Nan Zhang, Wantao Wu, Zeyu Wang, Ziyu Dai, Xun Zhang, Liyang Zhang, Yu Peng, Weijie Ye, Wenjing Zeng, Zhixiong Liu, Q. Cheng   +13 more
semanticscholar   +1 more source

Functionalized MoS2 nanosheet-capped periodic mesoporous organosilicas as a multifunctional platform for synergistic targeted chemo-photothermal therapy [PDF]

, 2018
The combination of different therapies into a single platform has attracted increasing attention as a potential synergistic tumor treatment. Herein, the fabrication of a novel folate targeted system for chemo-photothermal therapy by using thioether ...
Bremner, David H., Li, Heyu, Niu, Shi-Wei, Wang, Haijun, Wu, Huanling, Wu, Jian-rong, Wu, Junzi, Zhu, Li-Min   +7 more
core   +1 more source

Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats

Frontiers in Behavioral Neuroscience, 2021
Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and vascular injury in the brain. Puerarin (Pur) represents the major isoflavone glycoside of Radix Puerariae, with verified neuroprotective ...
Tiantian Zhu, Tiantian Zhu, Tiantian Zhu, Moli Zhu, Moli Zhu, Moli Zhu, Yue Qiu, Yue Qiu, Yue Qiu, Zeqing Wu, Zeqing Wu, Zeqing Wu, Ning Huang, Ning Huang, Ning Huang, Guangrui Wan, Guangrui Wan, Guangrui Wan, Jian Xu, Jian Xu, Jian Xu, Ping Song, Ping Song, Ping Song, Shuangxi Wang, Shuangxi Wang, Shuangxi Wang, Yaling Yin, Yaling Yin, Yaling Yin, Peng Li, Peng Li, Peng Li   +32 more
doaj   +1 more source

Evolution of Molecular Targeted Cancer Therapy: Mechanisms of Drug Resistance and Novel Opportunities Identified by CRISPR-Cas9 Screening

Frontiers in Oncology, 2022
Molecular targeted therapy has revolutionized the landscape of cancer treatment due to better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a major challenge in clinical settings that hinders continuous clinical ...
Jue Hou, Zongsheng He, Tianxiang Liu, Dongfeng Chen, Bin Wang, Q. Wen, Xiaojia Zheng   +6 more
semanticscholar   +1 more source

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited [PDF]

, 2012
The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2)
Dumont, Daniel J., Plate, Karl H., Scholz, Alexander   +2 more
core   +1 more source

Emerging molecular targets and therapy for cholangiocarcinoma [PDF]

World Journal of Gastrointestinal Oncology, 2017
Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting.
Kayhanian, Hamzeh, Smyth, Elizabeth C., Braconi, Chiara   +2 more
openaire   +5 more sources

Drug-therapy networks and the predictions of novel drug targets [PDF]

Journal of Biology 2008, 7:20, 2008
Recently, a number of drug-therapy, disease, drug, and drug-target networks have been introduced. Here we suggest novel methods for network-based prediction of novel drug targets and for improvement of drug efficiency by analysing the effects of drugs on the robustness of cellular networks.
arxiv   +1 more source